Gene LRR8_b-1 (S.moellendorffii)

LRR8_b-1

Species: S.moellendorffii
Alias: LRR8_b-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_b-1.AA Protein None 1078 None Fasta, JSON
LRR8_b-1.NA RNA None 3237 None Fasta, JSON
LRR8_b-1.kin_dom Protein Kinase Domain None 200 None Fasta, JSON

Protein domain

Protein domains of LRR8_b-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR8_b-1.AA LRRNT_2 24-67 38 2.7e-10 36.35 Pfam 1-46 (46) Show / Hide 
Range on Protein: 24-67
Range on HMM: 1-46/46
Sequence Identity: 38% (18 aa)

PSPEAKALLALLGSAQGSSR-SVLESSWNASQ--GDPCSGWIGVECS
.. .. ||||.  | ..|.. .   ||||.|   .|.|| | ||.|.
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCS-WTGVTCD
LRR_TYP LRR8_b-1.AA LRR_TYP 93-117 28 0.010611 16.03 SMART 1-24 (24) Show / Hide 
Range on Protein: 93-117
Range on HMM: 1-24/24
Sequence Identity: 28% (7 aa)

LTSLQTLNLSSANISSQIPPQLGNC
|..|..|.||. .. ...||.. ..
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_b-1.AA LRR_1 95-117 35 0.016354 13.08 Pfam 1-26 (26) Show / Hide 
Range on Protein: 95-117
Range on HMM: 1-26/26
Sequence Identity: 35% (10 aa)

SLQTLNLSS-A--NIS-SQIPPQ-LGNC
.||.|.||.    |.. . |||  . |.
NLQHLDLSGCNCCNLTGH-IPPSCF-NL
LRR_1 LRR8_b-1.AA LRR_1 119-141 40 0.000414 18.74 Pfam 1-26 (26) Show / Hide 
Range on Protein: 119-141
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

GLTTLDLQH-N--QLIGKIPRE-LGNL
 |..|||.. |  .| |.|| . . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_b-1.AA LRR_1 143-165 33 0.001334 16.94 Pfam 1-26 (26) Show / Hide 
Range on Protein: 143-165
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLEELHLNH-N--FLSGGIPAT-LASC
||..|.|.. |   |.| ||   . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_b-1.AA LRR_TYP 141-165 36 0.064462 9.61 SMART 1-24 (24) Show / Hide 
Range on Protein: 141-165
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LVNLEELHLNHNFLSGGIPATLASC
|.||.||.|..| |   .|. . ..
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_b-1.AA LRR_1 167-189 37 0.000286 19.31 Pfam 1-26 (26) Show / Hide 
Range on Protein: 167-189
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

KLQLLYISD-N--HLSGSIPAW-IGKL
.|| |..|. |  .|.|.|| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_b-1.AA LRR_1 191-213 40 0.00685 14.42 Pfam 1-26 (26) Show / Hide 
Range on Protein: 191-213
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

KLQEVRAGG-N--ALTGSIPPE-IGNC
.||.   .| |   |||.|||. . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_b-1.AA LRR_TYP 189-213 32 0.324363 3.86 SMART 1-24 (24) Show / Hide 
Range on Protein: 189-213
Range on HMM: 1-24/24
Sequence Identity: 32% (8 aa)

LQKLQEVRAGGNALTGSIPPEIGNC
| .|.| . ..|.|| ..||.. ..
LPNLRELDLSNNQLT-HLPPGAFQG
LRR_1 LRR8_b-1.AA LRR_1 239-261 29 0.001009 17.37 Pfam 1-26 (26) Show / Hide 
Range on Protein: 239-261
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

KLRSLYLHQ-N--SLSGALPAE-LGNC
.|..|.|   |  .|.| .| . . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_b-1.AA LRR_TYP 237-261 36 0.012246 15.52 SMART 1-24 (24) Show / Hide 
Range on Protein: 237-261
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LTKLRSLYLHQNSLSGALPAELGNC
|..||.|.|. | |  .||... ..
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_b-1.AA LRR_1 215-237 37 0.357483 8.33 Pfam 1-26 (26) Show / Hide 
Range on Protein: 215-237
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLTILGFAT-N--LLTGSIPSS-IGRL
.|..| .   |   |||.||.| .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_b-1.AA LRR_1 287-309 37 0.000373 18.9 Pfam 1-26 (26) Show / Hide 
Range on Protein: 287-309
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLEALWIWN-N--SLEGSIPPE-LGNC
||. | . . |  .|.|.|||. . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_b-1.AA LRR_TYP 285-309 36 0.097708 8.13 SMART 1-24 (24) Show / Hide 
Range on Protein: 285-309
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LQNLEALWIWNNSLEGSIPPELGNC
| ||. |   || |  ..||.. ..
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_b-1.AA LRR_1 263-285 37 0.343822 8.39 Pfam 1-26 (26) Show / Hide 
Range on Protein: 263-285
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

HLLELSLFE-N--KLTGEIPYA-YGRL
.| .|.|   |  .|||.||      |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_b-1.AA LRR_1 335-357 48 2.1e-05 23.35 Pfam 1-26 (26) Show / Hide 
Range on Protein: 335-357
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

QLQYLDLSL-N--RLTGSIPVE-LSNC
.||.||||  |  .|||.|| . . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_b-1.AA LRR_TYP 333-357 40 0.034349 11.85 SMART 1-24 (24) Show / Hide 
Range on Protein: 333-357
Range on HMM: 1-24/24
Sequence Identity: 40% (10 aa)

LKQLQYLDLSLNRLTGSIPVELSNC
| .|. |||| |.|| ..| .. ..
LPNLRELDLSNNQLT-HLPPGAFQG
LRR_1 LRR8_b-1.AA LRR_1 311-333 37 0.916608 6.88 Pfam 1-26 (26) Show / Hide 
Range on Protein: 311-333
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLVQLDIPQ-N--LLDGPIPKE-LGKL
||  ||.   |   | | ||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_b-1.AA LRR_1 383-405 33 0.000783 17.76 Pfam 1-26 (26) Show / Hide 
Range on Protein: 383-405
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

HLETLNVWD-N--ELTGTIPAT-LGNC
.|..|.. . |   |||.||   . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_b-1.AA LRR_TYP 381-405 28 0.10811 7.77 SMART 1-24 (24) Show / Hide 
Range on Protein: 381-405
Range on HMM: 1-24/24
Sequence Identity: 28% (7 aa)

LEHLETLNVWDNELTGTIPATLGNC
| .|..|.  .| || ..|. . ..
LPNLRELDLSNNQLT-HLPPGAFQG
LRR_1 LRR8_b-1.AA LRR_1 359-381 29 0.624875 7.47 Pfam 1-26 (26) Show / Hide 
Range on Protein: 359-381
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

FLVDIELQS-N--DLSGSIPLE-LGRL
 |  . |.. |   |.|.|| . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_b-1.AA LRR_1 407-429 33 0.00694 14.4 Pfam 1-26 (26) Show / Hide 
Range on Protein: 407-429
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

QLFRIDLSS-N--QLSGPLPKE-IFQL
.| ..|||. |  .|.| .|.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_b-1.AA LRR_1 431-453 29 0.131504 9.87 Pfam 1-26 (26) Show / Hide 
Range on Protein: 431-453
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

NIMYLNLFA-N--QLVGPIPEA-IGQC
|. .|.|   |  .|.| ||.  . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_b-1.AA LRR_1 503-525 48 7.2e-05 21.44 Pfam 1-26 (26) Show / Hide 
Range on Protein: 503-525
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

SLQMLDLHG-N--QLSGSIPTT-FGGL
.|| ||| | |  .|.|.||   | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_b-1.AA LRR_1 527-549 48 0.000692 17.95 Pfam 1-26 (26) Show / Hide 
Range on Protein: 527-549
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

NLYKLDLSF-N--RLDGSIPPA-LGSL
|| .||||  |  .| |.|||  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_b-1.AA LRR_1 455-477 37 0.003649 15.39 Pfam 1-26 (26) Show / Hide 
Range on Protein: 455-477
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLNRLRLQQ-N--NMSGSIPES-ISKL
.| .| |.  |  |..|.||.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_b-1.AA LRR_1 479-501 33 0.011149 13.67 Pfam 1-26 (26) Show / Hide 
Range on Protein: 479-501
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLTYVELSG-N--RFTGSLPLA-MGKV
||..  ||| |  ..||..|     . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_b-1.AA LRR_TYP 501-524 41 0.019145 13.93 SMART 1-24 (24) Show / Hide 
Range on Protein: 501-524
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

VTSLQMLDLHGNQLSGSIPTTFGG
 ..|. |||..|||.   | .|.|
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP LRR8_b-1.AA LRR_TYP 525-549 44 0.01947 13.87 SMART 1-24 (24) Show / Hide 
Range on Protein: 525-549
Range on HMM: 1-24/24
Sequence Identity: 44% (11 aa)

LGNLYKLDLSFNRLDGSIPPALGSL
|.|| .||||.|.|  ..|| . . 
LPNLRELDLSNNQL-THLPPGAFQG
LRR_TYP LRR8_b-1.AA LRR_TYP 477-500 41 0.460849 2.61 SMART 1-24 (24) Show / Hide 
Range on Protein: 477-500
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

LPNLTYVELSGNRFTGSLPLAMGK
||||.   ||.|..|   | | . 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 LRR8_b-1.AA LRR_1 551-573 25 0.548769 7.67 Pfam 1-26 (26) Show / Hide 
Range on Protein: 551-573
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

DVVLLKLND-N--RLTGSVPGE-LSGC
    | |.. |  .|||..| . . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_b-1.AA LRR_1 575-597 44 0.003397 15.5 Pfam 1-26 (26) Show / Hide 
Range on Protein: 575-597
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

RLSLLDLGG-N--RLAGSIPPS-LGTM
.|  |||.| |  .| |.|||| .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_b-1.AA LRR_1 624-645 44 0.000153 20.27 Pfam 1-26 (26) Show / Hide 
Range on Protein: 624-645
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

RLESLDLSH-N--NLTGTLAP--LSTL
.|..||||. |  ||||.. |  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_b-1.AA LRR_1 604-622 43 0.020395 12.74 Pfam 5-26 (26) Show / Hide 
Range on Protein: 604-622
Range on HMM: 5-26/26
Sequence Identity: 43% (10 aa)

LNLSF-N--QLQGPIPKE-FLHL
|.||  |  .|.| ||.. | .|
LDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_b-1.AA LRR_TYP 622-646 48 0.104525 7.89 SMART 1-24 (24) Show / Hide 
Range on Protein: 622-646
Range on HMM: 1-24/24
Sequence Identity: 48% (12 aa)

LSRLESLDLSHNNLTGTLAPLSTLG
|. |..||||.|.|| .| |    |
LPNLRELDLSNNQLT-HLPPGAFQG
LRR_1 LRR8_b-1.AA LRR_1 646-670 35 0.115487 10.07 Pfam 1-26 (26) Show / Hide 
Range on Protein: 646-670
Range on HMM: 1-26/26
Sequence Identity: 35% (10 aa)

GLSYLNVSF-N--NFKGPLPDSPVFRNM
 | .|..|  |  |. | .|.|  | |.
NLQHLDLSGCNCCNLTGHIPPS-CF-NL
Kinase LRR8_b-1.AA TKL 775-1042 22 1.4e-64 220.91 In-house 1-364 (364) Show / Hide 
Range on Protein: 775-1042
Range on HMM: 1-364/364
Sequence Identity: 22% (86 aa)

IGRGSSGTVYKCAMPN---------GEVLAVKSLWMTT-KGESSSGI----------------------PFELEVD-TLSQIRHRNILRLLGYCTNQDT-
||.|..|.|||    .         |.. ||| . ..  . ....                         || |.   .|..|| ||....|||.. .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------MLLLYEFMPNGSLADLLLEQKSLDWTVRYNIALGAAEGLAYLHHDSV-----PPIVHRDIKSTNILIDSQLE--------------AR
            . . .|..|.||| ..|.      | .| ..||..| |..||| .       |||.|||.|| |||.|. ..              . 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IADFGVAKLMDVS-----------------RSAKTVSRIAGSYGYIAPEY-----GYT-----------LKITTKNDVYAFGVVLLEILTNKRAVEHEFG
|.||| .. |. |                 ...|| ... |.... |||       ||           .. ..| |||.||.|| |||| .|  ...  
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

EGVDLVKWIREQLKTSASAVEVLEPRM--------QGMPDPEVQEMLQVLGIALLCTNSKPSGRPTMREVVVLL
. ... .   ...  .  ... | | .          |  |. . . ..  ..  | ...|. ||.. |..  |
MPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHK-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR8_b-1.AA IRAK 770-1042 30 1.1e-56 194.61 In-house 2-317 (317) Show / Hide 
Range on Protein: 770-1042
Range on HMM: 2-317/317
Sequence Identity: 30% (97 aa)

VSSNVIGRGSSGTVYKCAMPNGE-VLAVKSLWMTTKGE-SSSGIPFEL---EVDTLSQIRHRNILRLLGYCTNQDTMLLLYEFMPNGSLADLLLEQK---
  .|.|| |  |.||.  . | . . ||| |  . . .  .. . |     |. ... .|| ||. |.||||  .   | |..|||||| | |  |.   
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

S---LDWTVRYNIALGAAEGLAYLHHDS-VPPIVHRDIKSTNILIDSQLEARIADFGVAKLM---DVSRSAKT----VSRIAGSYGYIAPEYGY--TLKI
.   | |  |  |..|.| |. .|| ..   || |.|||| ||| | .... |.||| .       .. ...     .|.. |.  | .||. .  . ..
PPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQL

TTKNDVYAFGVVLLEILTNKRAVEHEFGE---GVDLVKWIREQLKT--SASA--------------------VEVLEPRMQGMPDPEVQEMLQVLGIALL
|.| ||| ||.||||.||  |||  .  |    .||.  | |. .   |                       .  . .|| ..|  ...||.|.   |. 
TKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQC---ACC

CTNSKPSGRPTMREVVVLL
|.  .   |..|..|. .|
CGHHRANRRCDMAWVMQQL
Kinase LRR8_b-1.AA TKL-Unique 771-969 31 2.2e-45 157.1 In-house 1-226 (290) Show / Hide 
Range on Protein: 771-969
Range on HMM: 1-226/290
Sequence Identity: 31% (71 aa)

SSNVIGRGSSGTVYKCAMPNGEVLAVKSLWMTTKGESSSGIPFELEVDTLSQIR-HRNILRLLGYCT----NQDTMLLLYEFMPNGSLADLLL-------
 .|.||.|..|.||| .. .|.  |.|..    . ....   || || ... .. | ||... |||.     .  | .  |..| ||| |.|        
FWNKIGEGGYGQVYK-GKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

---EQKSLDWTVRYNIALGAAEGLAYLHHDSVPPIVHRDIKSTNILIDSQ-----LEARIADFGVAKLMDVSRSAKTVSRI--------AGSYGYIAPEY
   . . |.. .|...|. .| |. |||| . | | |||.||.|.|.|.      . ..|.||| .|. . .....|....         ||. ..||| 
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNS-KINKMTNNEHKGTRNQTRCGSFRWMAPEV

GYT--LKITTKNDVYAFGVVLLEILTNKR
      ....| |||.||.|| ||.|.|.
LRMNFCQYSEKSDVYSFGIVLWEIATRKI
Kinase LRR8_b-1.AA MLK 769-966 29 2.9e-39 133.88 In-house 1-231 (291) Show / Hide 
Range on Protein: 769-966
Range on HMM: 1-231/291
Sequence Identity: 29% (70 aa)

LVSSNVIGRGSSGTVYKCAMPNGE----VLAVKSLWMTTKGESSS----GIPFELEVDTLSQIRHRN----ILRLLGYCTNQDT-MLLLYEFMPNGSLAD
.  . .|| ||.| |.|  . | .    ..|||    ..  ..|.       || |.  |. ..|.|    | ...| |...    ... |....|||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LLLEQKS--------------LDWTVRYNIALGAAEGLAYLHHDSVPPIVHRDIKSTNILIDS------QLEARIADFGVAKLMDVSRSAKTVSRIAGSY
.| ...|               |  .  |.||  |.|..||| . ..||.|||.|| |||||       .. ..|.|||...  |.... ..    ||.|
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR--DWHQMCTNMMSNAGTY

GYIAPEY---GYTLKITTKNDVYAFGVVLLEILT
 . |||        | . | ||. .|||| |.||
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLT
Pkinase LRR8_b-1.AA Pkinase 769-968 25 6e-39 138.8 Pfam 1-209 (293) Show / Hide 
Range on Protein: 769-968
Range on HMM: 1-209/293
Sequence Identity: 25% (55 aa)

LVSSNVIGRGSSGTVYKCAMPNGEV-LAVKSLWMTTKGESSSGIPFE-LEVDTLSQIRHRNILRLLGYCTNQDTMLLLYEFMPNG----SLADLLL--EQ
..   .||.||.|.||||   . .   ||| ..  .. ..   . .   |.  .  ..| ||.||...... | . .  |....|    .|.|..   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KSL--DWTVRYNIALGAAEGLAYLHHDSVPPIVHRDIKSTNILIDSQLEA----RIADFGVAKLMDVSRSAKTVSRIAGSYGYIAPEY-GYTLKITTKND
...  .. .  ....  ..||.|.|      |.|||.|. |||||.. .     .|.|||.||..|   .    . ..|...|.|||      ....| |
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VYAFGVVLLEILTNK
....|..| | |. .
MWSCGCILYEMLCGR
Kinase LRR8_b-1.AA RIPK 775-975 27 6e-34 113.07 In-house 1-232 (290) Show / Hide 
Range on Protein: 775-975
Range on HMM: 1-232/290
Sequence Identity: 27% (65 aa)

IGRGSSGTVYKCA-MPNGEVLAVKS---LWMTTKGESSSGIPFELEVDTLSQIRHRNILRLLGYCTNQDT------MLLLYEFMPNGSLADLLLEQKS--
.|.|..|.|.|.     |...|.|    . . |. ...       |.  . ..|...|....| |   .       . .  |.|.||||...|  . .  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LDWTVRYNIALGAAEGLAYLHHDSVPPIVHRDIKSTNILIDSQLEARIADFGVAKLMDVSRSAK----------TVSRIA-GSYGYIAPEYGY--TL
   . | .|  .    ..|  || |.  ||| ||| |  |||.|. . . |||||.|. |  | | .          . |.   |   |..||       
HHPDPWPLRCRMIHEISCGMCYL-HSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

KI----TTKNDVYAFGVVLLEILTNKRAVEHEF
|     |.| ||| |..|. |.||.| . | ..
KPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRK
Kinase LRR8_b-1.AA Dicty4 816-966 34 1.8e-33 109.09 In-house 48-212 (277) Show / Hide 
Range on Protein: 816-966
Range on HMM: 48-212/277
Sequence Identity: 34% (58 aa)

EVDTLSQIRHRNILRLLGYCT----NQDTMLLLYEFMPNGSLADLLLE-------QKSLDWTVRYN---IALGAAEGLAYLHH-DSVPPIVHRDIKSTNI
||. ...||| ||. ..|.||    .  .|.   |.|| |.|. ||.         ..|||. .     .|. || |...||  ..|  |.|||.|| |.
EVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNL

LIDSQLEARIADFGVAKLMDVSRSAKT-VSRIAGSYGYIAPEYGYTLKITTKNDVYAFGVVLLEILT
|.|  . . ..||| ...|    . |.  .  .|. .. |||       . | ||| || || ||||
LVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILT
Kinase LRR8_b-1.AA TK 769-967 15 4.9e-33 107.5 In-house 1-390 (486) Show / Hide 
Range on Protein: 769-967
Range on HMM: 1-390/486
Sequence Identity: 15% (62 aa)

LVSSNVIGRGSSG---TVYKC--------------------------AMPNGEVLAVKSLWMTTKGESSSGI--------------PFELEVDTLSQ--I
..  ...|.|  |   .|||.                             . .  ||| |  ..  ..   .               . .|   ...   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHRNILRLLGYCTNQDT------------MLLLYEFMPNGS----LADLLLEQKS---------------------------------------------
.| ||.||.|.|| ...            .... |.||.|.    | | | . .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDWTVRYNIALGAAEGLAYLHHDSV---PPIVHRDIKSTNILIDSQLE-----------ARIADFGVAK
                               |.   .  ... .|.|..|||   .   . .||||.   |.|.....            ..||||| ..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

LMD--VSRSAKT--VSRIAGSYG----------------------------YIAPEYGY---------TLKITTKNDVYAFGVVLLEILTN
 .    .|        . ..|||                            . |||            . | ||| ||..|||.. ||.|.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTY
Kinase LRR8_b-1.AA LRRK 769-973 24 4.8e-31 107.05 In-house 1-285 (351) Show / Hide 
Range on Protein: 769-973
Range on HMM: 1-285/351
Sequence Identity: 24% (70 aa)

LVSSNVIGRGSSG-TVYKCAMPN---------------------------GEVLAVKSLWMT-------------------------------TKGESSS
|.. . ||||..| .||.  . .                           ..  |.|.. ..                                 . . .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

GIPFELEVDTLSQIRHRNILRLLGYCTNQDTMLLLYEFMPNGSLADLLLEQK---------SLDWTVRYNIALGAAEGLAYLHHDSVPPIVHRDIKSTNI
   |  ||  .|  .| ||. |.|.| .  .| .  |..|.|.| ..| . |         ...|.... |||  |.|..|| |.. |||.||| || ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVM--EYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNI

LI---D---------SQLEARIADFGVAKLMDVSRSAKT-VSRIAGSYGYIAPE-YGYT--LKITTKNDVYAFGVVLLEILTNK-RAVEH
|.   .          .  | |||||    |  .   .. ...  |  |. |||  .|.     |.| |.|.||..| |.|| . .. ..
LLWSSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDE
Kinase LRR8_b-1.AA DRK 816-966 34 1.5e-29 97.25 In-house 47-197 (258) Show / Hide 
Range on Protein: 816-966
Range on HMM: 47-197/258
Sequence Identity: 34% (52 aa)

EVDTLSQIRHRNILRLLGYCTNQDTMLLLYEFMPNGSLADLLLEQK-SLDWTVRYNIALGAAEGLAYLHHDSVPPIVHRDIKSTNILIDSQLEARIADFG
|.. ..| || ||   .| |.|    .   |.|| |||.  |.... ..||  .  ... .| |. |||  . | |.||| || | |.|      .||||
EINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQVKVADFG

VAKLMDVSRSAKTVSRIAGSYGYIAPEYGYTLKITTKNDVYAFGVVLLEILT
 .      .. |.     |  . .|||       | | ||| |..|| |..|
LSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVT
Kinase LRR8_b-1.AA S_TKc 769-1042 20 1.2e-27 99.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 769-1042
Range on HMM: 1-231/231
Sequence Identity: 20% (59 aa)

LVSSNVIGRGSSGTVYKCAMPN-GEVLAVKSLWMTTKGESSSGIPFELEVDTLSQIRHRNILRLLGYCTNQDTMLLLYEFMPN--GSLADLLLEQKS---
    ..||.|. |.||||   . |.. |.| .           . .. |.. |.. .| || .|.... . | . .  |....  |.| |.. ....   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LDWTVRYNIALGAAEGLAYLHHDSVPPIVHRDIKSTNILIDSQLEARIADFGVAKLMDVSRSAKTVSRIAGSYGYIAPEYGYTLKITT-KNDVYAFG
   ..  .   ..   ...|.|.|  |   |.|||.|  |||.|.  .  |.|||.|...         . . |.  |.|||     . .. | |....|
RFPFPE-HARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

VVLLEILTNKRAVEHEFGEGVDLVKWIREQLKTSASAVEVLEPRMQGMPDPEVQEMLQVLGIALLCTNSKPSGRPTMREVVV---------LL
..| | |. .   .    .   . | |.                             ... .   | .  |. |||  |.            .
CILYEMLCGYPPFP----QMQMMFKKIG---------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8_b-1.AA STE 769-966 20 1.4e-27 94.47 In-house 1-263 (359) Show / Hide 
Range on Protein: 769-966
Range on HMM: 1-263/359
Sequence Identity: 20% (56 aa)

LVSSNVIGRGSSGTVYKCAMPN----------------GEVLAVKSLWMTTKGESSSG--------------I-PFELEVDTLSQIR--HRNILRLLGYC
.    .||.|..|||||..  .                ||. |.| . . ..  ..                .  .. |...... .  | || . .|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

TNQ-------DTMLLLYEFMPNGSLADLLLE----QKSLD----------WTVRYNIALGAAEG-LAYLHHDSVPPIVHRDIKSTNILIDSQLEARIADF
 .        |.  .  |.|..||| |.. .    .|.|.           ..   |.    .| |.|||      |.|||||. |||.     . ..||
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDF

GVAKLMDVS--------------RSAKTVSRIAGSYGYIAPEYGYT------LKITTKNDVYAFGVVLLEILT
||.. .. |               ...    ..|.  . |||           . .|| |.. .| ...| .|
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMAT
Kinase LRR8_b-1.AA Pkinase_Tyr 769-966 27 1.2e-25 87.48 Pfam 1-209 (270) Show / Hide 
Range on Protein: 769-966
Range on HMM: 1-209/270
Sequence Identity: 27% (61 aa)

LVSSNVIGRGSSGTVYKCAMP-----NGEVLAVKSLWMTTKGESSSGIP-----FELEVDTLSQI-RHRNILRLLGYCT-NQDT--MLLLYEFMPNGSLA
..   ..|.|. |.|||. .      ..   |||.|      |...        |  |. ...|. .| ||.||.| ||  ..   ...  |.||.|.| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-K----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

DLLLE----QKSLDWTVRYNIALGAAEGLAYLHHDSVPPIVHRDIKSTNILIDSQLEARIADFGVAKLM-------DVSRSAKTVSRIAGSYGYIAPEYG
| | .    ...|.     ....  |.|..||.      ..|||.   |.|..... ..|.||| |...        .. ..|    |       |||  
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK--LPIKWM----APECI

YTLKITTKNDVYAFGVVLLEILT
 . | ||| ||..|||.. ||.|
NYGKFTTKSDVWSFGVLMWEIFT
Kinase LRR8_b-1.AA TyrKc 769-1042 22 3.4e-19 71.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 769-1042
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

LVSSNVIGRGSSGTVYKCAMPNGEVLAVKSLWMTTKGESSSGIPFELEVDTLSQI--RHRNILRLLGYCTNQ-------DTMLLLYEFMPNGSLADLLLE
..   ..|.|  |.|||. .   .  |||.|   .         |  |   ....  .| ||.||.|.|| |       . .... |.||.|.| | | .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QKS-LDWTVRYNIALGAAEGLAYLHHDSVPPIVHRDIKSTNILIDSQLEARIADFGVAKLMDVS------RSAKTV----SRIA-GSYGYIAPEYGYTLK
 .  | .    .... .|.| .|||.    ...|||.   |.|..... ..|.||| ..  .         . ...    .. .   .   |||   . |
HRPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

ITTKNDVYAFGVVLLEILTNKRAVEHEFG------EGVDLVKWIREQLKTSASAVEVLEPRMQGMPDPEVQEMLQVLGIALLCTNSKPSGRPTMREVVVL
 ||| ||..|||.. ||.|  .  .   |      .  ........       .     | |     ..  . .    | . | . .|. |||..|.. .
FTTKSDVWSFGVCMWEIFT--YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSF---VCCPDEMYQ--IMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase LRR8_b-1.AA TK 1020-1042 26 0.001 7.52 In-house 464-486 (486) Show / Hide 
Range on Protein: 1020-1042
Range on HMM: 464-486/486
Sequence Identity: 26% (6 aa)

IALLCTNSKPSGRPTMREVVVLL
. . | . .|. |||.....  |
LMQQCWHYDPEDRPTFSQLHEQL
Kinase LRR8_b-1.AA MLK 1024-1042 42 0.003242 7.16 In-house 273-291 (291) Show / Hide 
Range on Protein: 1024-1042
Range on HMM: 273-291/291
Sequence Identity: 42% (8 aa)

CTNSKPSGRPTMREVVVLL
| |..|. ||..|..|  |
CWNQDPHKRPSFRQIVQHL
Kinase LRR8_b-1.AA LRRK 1023-1044 27 0.005312 6.44 In-house 330-351 (351) Show / Hide 
Range on Protein: 1023-1044
Range on HMM: 330-351/351
Sequence Identity: 27% (6 aa)

LCTNSKPSGRPTMREVVVLLRE
.| . .|  ||.. ..|  | .
HCWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8_b-1.AA DRK 1024-1044 38 0.017128 4.3 In-house 238-258 (258) Show / Hide 
Range on Protein: 1024-1044
Range on HMM: 238-258/258
Sequence Identity: 38% (8 aa)

CTNSKPSGRPTMREVVVLLRE
| |  |. ||.| |..  |  
CWNEDPQHRPSMQECLERLEA
Kinase LRR8_b-1.AA Dicty4 769-785 47 0.037879 3.16 In-house 1-17 (277) Show / Hide 
Range on Protein: 769-785
Range on HMM: 1-17/277
Sequence Identity: 47% (8 aa)

LVSSNVIGRGSSGTVYK
..  . ||.|| |.|||
INIEQRIGKGSFGEVYK
Kinase LRR8_b-1.AA Pkinase_Tyr 1022-1042 33 0.243765 5.16 Pfam 250-270 (270) Show / Hide 
Range on Protein: 1022-1042
Range on HMM: 250-270/270
Sequence Identity: 33% (7 aa)

LLCTNSKPSGRPTMREVVVLL
..| . .|. |||..|..  |
KQCWHYDPEDRPTFSEIHEQL
Kinase LRR8_b-1.AA TKL-Unique 1024-1042 36 0.300431 0.38 In-house 272-290 (290) Show / Hide 
Range on Protein: 1024-1042
Range on HMM: 272-290/290
Sequence Identity: 36% (7 aa)

CTNSKPSGRPTMREVVVLL
| .. || ||.  |..  |
CWHHDPSQRPSFDEIIHRL