Gene LRK19_o (S.moellendorffii)

LRK19_o

Species: S.moellendorffii
Alias: LRK19_o
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRK19

Sequence

Name Sequence Type Origin Length Description Download
LRK19_o.AA Protein None 243 None Fasta, JSON
LRK19_o.NA RNA None 732 None Fasta, JSON
LRK19_o.kin_dom Protein Kinase Domain None 152 None Fasta, JSON

Protein domain

Protein domains of LRK19_o.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LRK19_o.AA TKL 24-172 23 3.1e-44 153.3 In-house 1-214 (364) Show / Hide 
Range on Protein: 24-172
Range on HMM: 1-214/364
Sequence Identity: 23% (52 aa)

LGQGGSGSVFKGVLPD---------GRLVAVKRIGGSG-------------------------------KQFRAEVMAVGRIHHLNLVRLLWFCIKSPL-
.|.||.| |.||..           |. ||||..                                   .... |.|   |..| |.|... .|. .|  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------HFLVYEFMPNGSLDSWIFGKGRYLDWSSRVSIAMDVARGLAYLHD----SCREK--IFHLDIKPQNILLDGKMR--------------
            ...|.|..|.||| . .        |. |...|.|.|||..|||     .|. |  | | |.|..|||.| ...              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKISDFGFAKIVDKDKSQTITG
.||.|||... ........ |.
CKICDFGLSRFMSQSGNMNDTM
Kinase LRK19_o.AA MLK 18-175 23 3.5e-32 109.0 In-house 1-195 (291) Show / Hide 
Range on Protein: 18-175
Range on HMM: 1-195/291
Sequence Identity: 23% (47 aa)

FGAGSKLGQGGSGSVFKGVLPDGRL-----VAVKRIGGSG----------KQFRAEVMAVGRIHHLN----LVRLLWFCIKSPLH-FLVYEFMPNGSLDS
.    ..| |..|.|.||.   ...     |||||.  .           ..|. |.. . .. |.|     ....  |...| | ..| |....||| .
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

WIFG-KG------------RYLDWSSRVSIAMDVARGLAYLHDSCREKIFHLDIKPQNILLD------GKMRAKISDFGFAKIVDKDKSQTITGLHG
 . | ..            |  | .. ...|...|||..|||   . .| | |.|..|||.|      ... .||.||| .. . . . .. ..  |
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAG
Kinase LRK19_o.AA TKL-Unique 20-195 30 4.3e-32 110.52 In-house 1-188 (290) Show / Hide 
Range on Protein: 20-195
Range on HMM: 1-188/290
Sequence Identity: 30% (61 aa)

AGSKLGQGGSGSVFKGVLPDGRLVAVKRIG----GSGK--Q-FRAEVMAVGRIH-HLNLVRLLWFCI----KSPLHFLVYEFMPNGSLDSWIF-------
 ..|.|.||.|.|.||. . |  ||.|..      | .  | |. ||    ..| | |.|..  .|.    . |  ..| |..| |||.. .        
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--GKGRYLDWSSRVSIAMDVARGLAYLHDSCREKIFHLDIKPQNILLDGK-----MRAKISDFGFAKIVDKDKSQTITGLHGARVAPFHDHRQDRRLQLR
   .   |... ||..| |.|.|. ||| .|  .| |.|.|..|.|.| .     ...||.|||..|. .|.   |.... | |             | |
NNNNNCKLNMQQRVKMAIDIAQGMYYLH-HCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR------------NQTR

CG
||
CG
Kinase LRK19_o.AA IRAK 18-159 32 2.2e-30 104.96 In-house 1-160 (317) Show / Hide 
Range on Protein: 18-159
Range on HMM: 1-160/317
Sequence Identity: 32% (52 aa)

FGAGSKLGQGGSGSVFKGVLPDGR-LVAVK--------RIGGSGKQFRA---EVMAVGRIHHLNLVRLLWFCIKSPLHFLVYEFMPNGSLDSWIFGKGR-
| .. ..|.|| | |..|..      .|||         .... ..|..   |. .  |..| |.| |. .|.... | |||..||||||     . .  
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

-Y---LDWSSRVSIAMDVARGLAYLHDSC-REKIFHLDIKPQNILLDGKMRAKISDFGFA
     | |  |.||.   |.|. .||.      | | |||. |||||  . .||.||| .
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLH
Kinase LRK19_o.AA Pkinase 18-172 26 6.9e-30 106.75 Pfam 1-173 (293) Show / Hide 
Range on Protein: 18-172
Range on HMM: 1-173/293
Sequence Identity: 26% (47 aa)

FGAGSKLGQGGSGSVFKGVLPDGRL-VAVKRIGGSGKQFRA--------EVMAVGRIHHLNLVRLLWFCIKSPLHFLVYEFMPNG----SLDSWIF-GKG
.  |.|.|.|..|.|.|..  . .  ||||.|  ...            |.    |..| | |||. ..  ..   .| |....|    .| ..|   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RYL--DWSSRVSIAMDVARGLAYLHDSCREKIFHLDIKPQNILLDGKMRA----KISDFGFAK---IVDKDKSQTITG
. .  ..    ...  ..|||.|.|.    .| | |.||.|||.| ..      ||.|||.||   .  .   .|..|
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG
Kinase LRK19_o.AA Dicty4 18-169 28 2.3e-22 71.54 In-house 1-171 (277) Show / Hide 
Range on Protein: 18-169
Range on HMM: 1-171/277
Sequence Identity: 28% (50 aa)

FGAGSKLGQGGSGSVFKGVLPDGRLVAVKRI--GGSG------KQFRAEVMAVGRIHHLNLVRLLWFCI----KSPLHFLVYEFMPNGSLDSWIFG----
   ....|.|. |.|.||    |  ||||       .      . ||.||   . | | |.. ..  |.    ...    | |.|| |.| | .      
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

--KGRYLDWSSRVS---IAMDVARGLAYLHDSCREKIFHLDIKPQNILLDGKMRAKISDFGFAKIVDKDKSQT
  .   |||. . .   .| |.|||...|| .|   | |.|.|. |.| |  .|.|..|||....  |.....
QQQSIKLDWPLIKRAMRMAFDAARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHK
Kinase LRK19_o.AA RIPK 24-160 26 1.2e-21 70.46 In-house 1-157 (290) Show / Hide 
Range on Protein: 24-160
Range on HMM: 1-157/290
Sequence Identity: 26% (43 aa)

LGQGGSGSVFKGVLPDGRLVAVKRI--GGS---------GKQFRAEVMAVGRIHHLNLVRLLWFCIKS------PLHFLVYEFMPNGSLDSWIFGKGRY-
.| ||.| ||| .  . . ...| .  .            ..   |. .. .. . . |... ||..        |  .| |.|.||||      | .| 
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LDWSSRVSIAMDVARGLAYLHDSCREK--IFHLDIKPQNILLDGKMRAKISDFGFAK
   . |. |  .   ...|  |||.    .  | |.| ||.|||.|. . .||.||| |.
HHPDPWPLRCRMIHEISCGMCYLHS---MNPPIIHRDLKPENILVDNNFHVKIADFGLAT
Kinase LRK19_o.AA STE 18-172 20 2.7e-20 68.43 In-house 1-225 (359) Show / Hide 
Range on Protein: 18-172
Range on HMM: 1-225/359
Sequence Identity: 20% (48 aa)

FGAGSKLGQGGSGSVFKGVLPD----------------GRLVAVKRIG---------------------GSGKQFRAEVMAVGRIH--HLNLVRLLWFCI
.   .|.|.|..|.|.|..  .                |...|.|..                         .|.  |.    . .  | | |. .  ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KS-------PLHFLVYEFMPNGSLDSWIF---GKGR----------YLDWSSRVSIAMDVARG-LAYLHDSCREKIFHLDIKPQNILLDGKMRAKISDFG
|           ... |.|..||||. |    |.|.          ... |    |. .. .| |.|||.     | | ||||.||||     .|..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

FAKIVDKD------------------KSQTITG
........                  |..|..|
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVG
Kinase LRK19_o.AA TK 18-166 14 3.4e-20 63.71 In-house 1-313 (486) Show / Hide 
Range on Protein: 18-166
Range on HMM: 1-313/486
Sequence Identity: 14% (47 aa)

FGAGSKLGQGGSG---SVFKGVLPDGR--------------------------LVAVKRIG----GSGKQFRA----------------EVMAVGR---I
   | |||.|  |    |.|| . ...                           |||| .      | ..|..                |.|.. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHLNLVRLLWFCIKS------------PLHFLVYEFMPNGS----LDSWIFGKGRY--------------------------------------------
|| |.|||.  | ..            .   .| |.||.|.    |...   . ..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDWSSRVSIAMDVARGLAYLHDS----CREKIFHLDIKPQNILLDGKMR-----------AKISDFG--
                               |.   .. .....|.|..|||.        .. | |.   |.|.. ...           .||.|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------FAKIVDKDK
       |. ...|.
RQGSGVLARDIYSDD
Kinase LRK19_o.AA LRRK 18-157 22 1.8e-19 65.57 In-house 1-223 (351) Show / Hide 
Range on Protein: 18-157
Range on HMM: 1-223/351
Sequence Identity: 22% (50 aa)

FGAGSKLGQGGSG-SVFKGVLPD---------------------------GRLVAVKRIGGSG-------------------------------------
.  ....|.||.| .|... . .                           .  ||.| .   .                                     
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

-KQFRAEVMAVGRIHHLNLVRLLWFCIKSPLHFLVYEFMPNGSLDSWIF---GKGR-----YLDWSSRVSIAMDVARGLAYLHDSCREKIFHLDIKPQNI
   || ||    . .| |.| |. ||| .||  .| |..|.|.|.. ..     |.      ..|. .  ||...|.|..||| |.. .| | | |. ||
FREFRHEVWIMSHLNHPNIVSLKGFCI-HPL-CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH-SHNPPIIHRDLKSPNI

LL---D---------GKMRAKISDFG
||   .           . |||.|||
LLWSSPQNHSPNYPNAHVCAKIADFG
Kinase LRK19_o.AA Pkinase_Tyr 18-127 27 2.2e-19 66.29 Pfam 1-129 (270) Show / Hide 
Range on Protein: 18-127
Range on HMM: 1-129/270
Sequence Identity: 27% (35 aa)

FGAGSKLGQGGSGSVFKGVLP-----DGRLVAVKRI--GGSGKQ-----FRAEVMAVGRI-HHLNLVRLLWFCI-KSPL--HFLVYEFMPNGSLDSWIFG
   | |||.|  |.|.||..      ..  |||| .  | . .|     | .|.     . || |.|||.  |. ..    ...| |.||.|.|..    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

K---GRYLDWSSRVSIAMDVARGLAYLHD
.   .. |. .  .......|.|..||..
HREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase LRK19_o.AA Ciliate-E2 18-165 19 4.7e-19 62.02 In-house 1-209 (365) Show / Hide 
Range on Protein: 18-165
Range on HMM: 1-209/365
Sequence Identity: 19% (43 aa)

FGAGSKLGQGGSGSVFKGVL------------------------PDGRLVAVKRIGGSG-KQFRAEVMAVGRIH----------------HLNLVRLLWF
.    |.|||. |||.|.                           .. ..|.|..  .. .|.  |     .|.                | |.... ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CI--KSPLHFLVYEFMPNGSLDS-----WIFGKGR-----YLDWSSRVSIAMDVAR---------------GLAYLHDSCREKIFHLDIKPQNILLDGKM
 .  .    .|| |.   |.| .     ... .       |...  .  |   ...               .| |||   .  |.| ||||.|||.    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF----

RAKISDFGFAKIVDKD
  ||.|||..|..|.|
-IKIIDFGLSKKYDDD
Kinase LRK19_o.AA S_TKc 18-235 21 3.2e-14 31.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-235
Range on HMM: 1-231/231
Sequence Identity: 21% (58 aa)

FGAGSKLGQGGSGSVFKGVLPD-GRLVAVKRIGGSGKQFRAEVMAVGRIHHLNLVRLLWFCIKSPLHFLVYEFMPN--GSLDSWIFGKGR-----YLDWS
.  . |.|.|. |.|.|..  . ||.||.|.|    ...| |.    . || |.|.|. ..      ..| |....  |.| . |  .||     ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

SRVSIAMDVARGLAYLHDSCREKIFHLDIKPQNILLDGKMRAKISDFGFAKIVDKDKSQTITG----------LHGA-----------------RVAPFH
   ...  ....|.|.|.    .| | |.||.|||||   . ||.|||.|...      |. |           .|                  .  ||.
HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP

DHRQDRRLQLRCGFDRAGFDTAISRIFWHSTSTK--LGSLLS------LGSIRLLW-E-----SAWI
   |. ..  ..|                | . |  .  .|       ..   .|  |       |.
---QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRK19_o.AA TyrKc 18-221 18 3.2e-12 -24.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-221
Range on HMM: 1-280/280
Sequence Identity: 18% (52 aa)

FGAGSKLGQGGSGSVFKGVLPDGRLVAVKRIGGSG-KQFRAEVMAVGRI--HHLNLVRLLWFCIKS-------PLHFLVYEFMPNGSLDSWIFGKGRYLD
   | ||| |  | |.||..   . |||| .  .  . |. |     ..  || |.|||.  |...       . ...| |.||.|.|.. .  ... | 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

WSSRVSIAMDVARGLAYLHDSCREKIFHLDIKPQNILLDGKMRAKISDFGFAKIVDKD-----KSQTITGLH--GAR-----------------------
..  .|.. ..|.| .|||.    .. | |.   |.|.. . ..|||||| .. .. |      .....     |..                       
MKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

---------------VAPFHD------------HRQDRRLQLRCGFD--------RAGFDTAISRIFWHS------TSTKLGSLL
                 |  .            .. ...  ...  .               | .  ||       | . . ...
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LRK19_o.AA Pkinase_Tyr 142-165 36 0.024158 8.56 Pfam 141-165 (270) Show / Hide 
Range on Protein: 142-165
Range on HMM: 141-165/270
Sequence Identity: 36% (9 aa)

NILLDGKMRAKISDFGFAKIV-DKD
|.|.. .. .||.||| |. . ..|
NCLVTENNVVKICDFGLARDIYNDD