Gene IRAKm_o-1 (S.moellendorffii)

IRAKm_o-1

Species: S.moellendorffii
Alias: IRAKm_o-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKm

Sequence

Name Sequence Type Origin Length Description Download
IRAKm_o-1.AA Protein None 780 None Fasta, JSON
IRAKm_o-1.NA RNA None 2343 None Fasta, JSON
IRAKm_o-1.kin_dom Protein Kinase Domain None 197 None Fasta, JSON

Protein domain

Protein domains of IRAKm_o-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKm_o-1.AA B_lectin 97-139 28 4.2e-08 29.41 Pfam 66-120 (137) Show / Hide 
Range on Protein: 97-139
Range on HMM: 66-120/137
Sequence Identity: 28% (16 aa)

AASLVLQNSGNVLIYFY--N--G-SVWQS--FDFPSEFLLPTQILKT------GMR
......|.|||  .| .  |  .  .|||  ||.|.  .||.. | .      .|.
NCRAQMQDSGNLVLY-DDNNDSNNVLWQSNTFDHPTDTWLPGMKLGWDNNVTIYMN
Kinase IRAKm_o-1.AA TKL 484-762 22 1.7e-62 213.93 In-house 1-364 (364) Show / Hide 
Range on Protein: 484-762
Range on HMM: 1-364/364
Sequence Identity: 22% (87 aa)

LGAGGYGSVYKGVLSD---------GRVVAVKKLDYSGTQGA---------------------------KQFVTEIAGIGGISHVNIVKLCGFCIEGAT-
.| ||.| ||||..           |..|||||.     .                             .... ||  .  ..| |||.. |.|...   
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------QWLLVYEFMPNGSLDKWLFEQTSENLWLSWQQRIDIALGTAQGLAYLHE----ECREP--ILHLDIKPQNILLDTEFV-----------
           |  .|.|..|.|||   |           |.||...||..|.|..|||      |. .  |.| |.|..|||.|  .            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

---AKVADFGMAKLLENRNETQVMTTM-----------------RGTPGYMAPEWLT----------------HFMATKRCDVYSYGKVLLELIGGRRNI
   .|..||| .. ...... . . |.                 .|||..|||| |                 .| ....|||||.| || |.. ..|  
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR--

DLSKAVNFGDNTQPDESWYFPTWVVNQVEKGNFLEVIDERVRASASENYQ----------QAKKMVHLALWCIQDNADSRPSMRTIVEVL
             | .   ....... ...  |  |.|.. |    .  |            . |  |. .| . ....|||. .|.. |
-------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKm_o-1.AA Pkinase 483-762 21 1.5e-50 179.08 Pfam 6-293 (293) Show / Hide 
Range on Protein: 483-762
Range on HMM: 6-293/293
Sequence Identity: 21% (68 aa)

KLGAGGYGSVYKGVLSDGRV-VAVKKLDYSGTQGAKQFVT-----EIAGIGGISHVNIVKLCGFCIEGATQWLLVYEFMPNG----SLDKWLFEQTSENL
|.|.|..|.|||..  . .  ||||..... ..  .. .|     ||.    ..| |||.| ... ..   . .| |....|    .|  ..    ... 
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYIST--WRHG

WL--SWQQRIDIALGTAQGLAYLHEECREPILHLDIKPQNILLDTEFVA----KVADFGMAKLLENRNETQVMTTMRGTPGYMAPEWLT-HFMATKRCDV
..  |... ..... ...||.|.|..    |.| |.||.|||.| . .     |..||| ||...     . |||  |||.|||||..  . . ....|.
CFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSYGKVLLELIGGRRNIDLSKAVNFGDNTQPDESWYFPTW--VVNQVEKGNFLEVIDERVRASASENYQQA---------------------KKMVHLAL
.|.| .| |.. ||                      .| .  . .  .  . ...|... ..  ......                      . . ..  
WSCGCILYEMLCGR----------------------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK

WCIQDNADSRPSMRTIVEV--L
||.. .  .||. . |..   .
WCLCKDPKKRPTAEQILQHPWF
Kinase IRAKm_o-1.AA IRAK 481-683 38 2.1e-47 163.79 In-house 4-225 (317) Show / Hide 
Range on Protein: 481-683
Range on HMM: 4-225/317
Sequence Identity: 38% (85 aa)

STKLGAGGYGSVYKGVLSDGR-VVAVKKL----DYSGTQGAKQFVT---EIAGIGGISHVNIVKLCGFCIEGATQWLLVYEFMPNGSLDKWLFEQTSENL
. ..| ||.| ||.|...    ..|||||    | | ..  ..| .   |.     . | ||| | |.|.|.  .  |||..||||||   |  |.  . 
DNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQ-CHCLVYPYMPNGSLEDRLWCQDGQCP

W--LSWQQRIDIALGTAQGLAYLHEEC-REPILHLDIKPQNILLDTEFVAKVADFGMAKLL---ENRNETQV---MT-TMRGTPGYMAPEWLT--HFMAT
   |||.||..|..||| |. .||.     || | |||. |||||  |..| .|||..      ...  . .   || . |||  ||.|| ..      |
PKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLT

KRCDVYSYGKVLLELIGGRRNID
|. |||| | ||||.. |.|  .
KKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAKm_o-1.AA TKL-Unique 480-676 31 5.5e-41 142.3 In-house 1-222 (290) Show / Hide 
Range on Protein: 480-676
Range on HMM: 1-222/290
Sequence Identity: 31% (70 aa)

YSTKLGAGGYGSVYKGVLSDGRVVAVKKLDY---SGTQGAKQFVTEIAGIGGIS-HVNIVKLCGFCIE---GATQWLLVYEFMPNGSLDKWLF------E
 . |.|.||||.||||.   |  ||.|..     |  .  . |  |.  .  .  | |||.. |.|.     . .. .| |..| |||.. |        
FWNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

QTSENLWLSWQQRIDIALGTAQGLAYLHEECREPILHLDIKPQNILLDTE-----FVAKVADFGMAKLLENRNETQVM-------TTMRGTPGYMAPEWL
  ..|. |..|||...|.  |||. ||| .    |.|.|.|..|.|.| .     . .|..||| .|.. ..|.. .        .|  |.. .|||| |
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

TH--FMATKRCDVYSYGKVLLELI
.   .. .. .||||.| || |..
RMNFCQYSEKSDVYSFGIVLWEIA
Kinase IRAKm_o-1.AA MLK 478-676 25 7.1e-41 139.54 In-house 1-230 (291) Show / Hide 
Range on Protein: 478-676
Range on HMM: 1-230/291
Sequence Identity: 25% (60 aa)

KGYSTKLGAGGYGSVYKGVLSDGR----VVAVKKLD---YSGTQG----AKQFVTEIAGIGGISHVN----IVKLCGFCIEGATQWLLVYEFMPNGSLDK
   ....|.|..|.|.||.    .    .||||. .   .   .     ...| .|.     .|| |    |... | |..   . ..| |....|||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

WLFEQTSENL----------WLSWQQRIDIALGTAQGLAYLHEECREPILHLDIKPQNILLD------TEFVAKVADFGMAKLLENRNETQVMTTMRGTP
 | ...|.              . .. ...||  |.|..|||.. . || | |.|..|||.|       . ..|..||| .. . .. ..  |. ..||.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTN--MMSNAGTY

GYMAPEWL---THFMATKRCDVYSYGKVLLELI
 .|||| .    . . .. |||.|.| || |..
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase IRAKm_o-1.AA LISK 483-680 28 1e-35 113.39 In-house 1-237 (296) Show / Hide 
Range on Protein: 483-680
Range on HMM: 1-237/296
Sequence Identity: 28% (70 aa)

KLGAGGYGSVYKGVLS-DGRVVAVKKLD-------YSGTQGAKQFVTEIAGIGGISHVNIVKLCGFCIEGATQWLLVYEFMPNGSLDKWLFEQTSENLWL
..| |..|.|||| .  .|.|.|.|..        .  .|  | .  |.. .  ..| |||.  | | .   |  .| |..  | |   |.   .    |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQ--KFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPL

SWQQRIDIALGTAQGLAYLHEECREPILHLDIKPQNILLDTE----FVAKVADFGMAKLLENRNET---------------------------------Q
.|.||..|||. |.|..|||. .   |.| | | .|.|...     . .||.||| |.... .|                                   .
PWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKR

VMTTMRGTPGYMAPEWLTHFMATKRCDVYSYGKVLLELIGGRR
 ||   |||  |||| |.    . .|||.|.| ||.|.|....
RMTIC-GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVK
Kinase IRAKm_o-1.AA Dicty4-Unclassified 481-678 33 1.2e-35 119.59 In-house 4-204 (263) Show / Hide 
Range on Protein: 481-678
Range on HMM: 4-204/263
Sequence Identity: 33% (71 aa)

STKLGAGGYGSVYKGVLSDGRVVAVKKLDYSGTQGAK-----QFVTEIAGIGGISHVNIVKLCGFCIEG---ATQWLLVYEFMPNGSLDKWLFEQTSE-N
   .| |    |.||.   |. |||||.  ..   .       |  |..  | |.| | ||. | ||           | |||. | |      . || .
DQFIGKGHFSKVHKGNW-KGKDVAVKKFN-ENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQ

LWLSWQQ--RIDIALGTAQGLAYLHEECREPILHLDIKPQNILLDTEFVAKVADFGMAKLLENRNETQVMTTMRGTPGYMAPEWLTHFMATKRCDVYSYG
  ..      | .|.  |||...||   |. . | |||  |||.|  | .|.||||..   ..   .. |||  |||   .|| | |   . . |||||.
QPIKLDDTLIIKYAFDIAQGMQHLH--TRN-FIHRDIKSSNILMDKHFNIKIADFGISRVIDF---NFNMTTIAGTPKWESPECLMHESYNQKSDVYSYA

KVLLELIGG
 .| ||. |
MMLYELATG
Kinase IRAKm_o-1.AA S_TKc 478-762 22 3.6e-34 120.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 478-762
Range on HMM: 1-231/231
Sequence Identity: 22% (68 aa)

KGYSTKLGAGGYGSVYKGVLSD-GRVVAVKKLDYSGTQGAKQFVTEIAGIGGISHVNIVKLCGFCIEGATQWLLVYEFMPN--GSLDKWLFEQTSENLW-
     |.| |..|.|||..  . ||.||.|...       ...  ||.      | ||||| ... .  .   .| |....  |.| . . .. .. |  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSWQQRIDIALGTAQGLAYLHEECREPILHLDIKPQNILLDTEFVAKVADFGMAKLLENRNETQVMTTMRGTPGYMAPEWLTHFMATK-RCDVYSYGKV
 ..  .   ..  ....|.|.|.     |.| |.||.|||||.  . |..|||.|..|         ||. ||| ||||| |     .| .||..| | .
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LLELIGGRR----NIDLSKAVNFGDNTQPDESWYFPTWVVNQVEKGNFLEVIDERVRASASENYQQAKKMVHLALWCIQDNADSRPSMRTIVE-------
| |.. |.        . | .                                              . . ..   | | . . ||.   . .       
LYEMLCGYPPFPQMQMMFKKIG--------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

--VL
   .
HPWF
Kinase IRAKm_o-1.AA Dicty4 483-675 31 6.8e-33 107.16 In-house 6-210 (277) Show / Hide 
Range on Protein: 483-675
Range on HMM: 6-210/277
Sequence Identity: 31% (65 aa)

KLGAGGYGSVYKGVLSDGRVVAVKKL--DYSG--TQGAKQFVTEIAGIGGISHVNIVKLCGFCI---EGATQWLLVYEFMPNGSLDKWLFE---QTSENL
..| |..|.||||    |  ||||||  .  .      . |  |..  . |.| ||... | |.         . | |.|| |.| . |        .. 
RIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSI

WLSWQQRID---IALGTAQGLAYLHE-ECREPILHLDIKPQNILLDTEFVAKVADFGMAKLLENRNETQV-MTTMRGTPGYMAPEWLTHFMATKRCDVYS
 |.|  ..    .|. .|.|...||.  ..  |.|.|.|. |.| |  ...||.||| ...     . .  ..|. |||..|||| . |   .   ||||
KLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYS

YGKVLLEL
.| || |.
FGIVLWEI
Kinase IRAKm_o-1.AA STE 480-679 22 3e-32 111.24 In-house 1-265 (359) Show / Hide 
Range on Protein: 480-679
Range on HMM: 1-265/359
Sequence Identity: 22% (63 aa)

YST--KLGAGGYGSVYKGVLSD----------------GRVVAVKKLDYSGTQG-----------------AKQFVTEIAGIGGIS--HVNIVKLCGFCI
.    |.| |..|.|||..  .                |...|.|.....  .                   .|.  ||      .  | ||||  | ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EGA------TQWLLVYEFMPNGSLDKWLFE--QTSENL--------WLSWQQRIDIALGTAQG-LAYLHEECREPILHLDIKPQNILLDTEFVAKVADFG
 .       ..  .. |.|..||||. . .   . ..|        ... .| . |.  . .| |.|||.     | | ||||.||||     .| .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

MAKLLEN--------------RNETQVMTTMRGTPGYMAPEWLTHFM------ATKRCDVYSYGKVLLELIGGR
 .. |..               .  |  .|. ||| .|||| ..          . .||..| | ...|.. |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAKm_o-1.AA Pkinase_Tyr 483-669 28 1.1e-26 91.04 Pfam 6-201 (270) Show / Hide 
Range on Protein: 483-669
Range on HMM: 6-201/270
Sequence Identity: 28% (57 aa)

KLGAGGYGSVYKGVLS-----DGRVVAVKKL-DYSGTQG--AKQFVTEIAGIGGI-SHVNIVKLCGFCI-EGAT-QWLLVYEFMPNGSLDKWLFEQTSEN
|||.| .|.||||..      ..  ||||.| ...  .    . |  |..    . .| |||.| | |. .|   |...| |.||.|.|.. | .. ...
KLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDK

LWLSWQQRIDIALGTAQGLAYLHEECREPILHLDIKPQNILLDTEFVAKVADFGMAKLLENRNET-QVMTTMRGTPGYMAPEWLTHFMATKRCDVYSYG
  |. .. .....  |.|..||..     . | |.   |.|.. ..|.|..|||.|....|  .  .. .  .     |||| . .   |   ||.|.|
QPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFG
Kinase IRAKm_o-1.AA TK 483-669 16 2.2e-26 84.81 In-house 6-381 (486) Show / Hide 
Range on Protein: 483-669
Range on HMM: 6-381/486
Sequence Identity: 16% (61 aa)

KLGAGGYG---SVYKGVLSDGR--------------------------VVAVKKLD--YSGTQGAKQ---------------FVTEIAGIGG--ISHVNI
|||.| .|    |||| . ...                           |||| |    . .| ...               .. |..        | ||
KLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNI

VKLCGFCIEGATQ-----------WLLVYEFMPNGS----LDKWLF--EQTSENLW--------------------------------------------
|.| | | .|...           |..| |.||.|.    |...|     .  .                                              
VRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLI

--------------------------LSWQQRIDIALGTAQGLAYLHEE----CREPILHLDIKPQNILLDTEFV-----------AKVADFGMAK----
                          |. .|.. ...  |.|..|||.         . | |.   |.|.. . |           .|.||||...    
KDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSG

---LLENRNETQVMTTMRGTPG-------------------------YMAPEWLTHFM---------ATKRCDVYSYG
      ....  . .. .||..                         .|||| |..            |   ||.|.|
VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFG
Kinase IRAKm_o-1.AA TK-Unique 483-675 26 2.9e-26 87.62 In-house 6-232 (294) Show / Hide 
Range on Protein: 483-675
Range on HMM: 6-232/294
Sequence Identity: 26% (61 aa)

KLGAGGYGSVYKGVLSD-------GRVVAVKKLD-YSGTQGAKQFVTEIAGIGGIS-HVNIVKLCGFCIEGATQWLLVYEFMPNGSLDKWLFEQTSE---
..| | .| |..| ..         ..||||.|  ..  .  ..|  ||.    .  | |||...| |..   .|....|..|.|.|.. | .   .   
VIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQ

-----NLW--------------LSWQQRIDIALGTAQGLAYLHE---ECREPILHLDIKPQNILLDTEFVAKVADFGMAKLLENRNETQVMTTMRGTPG-
     ||               .| .. . .| . |.|..||..   ..     | |.   |.||   .|.|..|||||. ... |. ..|.. .|.   
HQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI----VHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQGRIPI

-YMAPEWLT--HFMA-TKRCDVYSYGKVLLEL
 .|||| |   | |. | . ||.|.| .. |.
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEI
Kinase IRAKm_o-1.AA TyrKc 481-762 21 3.7e-22 80.86 SMART 4-280 (280) Show / Hide 
Range on Protein: 481-762
Range on HMM: 4-280/280
Sequence Identity: 21% (68 aa)

STKLGAGGYGSVYKGVLSDGRVVAVKKLD-YSGTQGAKQFVTEIAGIGGI--SHVNIVKLCGFCIEGA------TQWLLVYEFMPNGSLDKWLFEQTSEN
  ||| | .| ||||...  . ||||.|  ..     . |  |.     .  .| |||.| | |...        . ..| |.||.|.|.. | .   . 
GKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

LWLSWQQRIDIALGTAQGLAYLHEECREPILHLDIKPQNILLDTEFVAKVADFGMAKLLENR----NETQVMTTMR--GTPG-----YMAPEWLTHFMAT
  |.... .....  |.| .|||.    .. | |.   |.|.. ....|..|||... ...      .... ...   |. .      |||| . . . |
--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KRCDVYSYGKVLLELI-------GG-----RRNIDLSKAVNFG-DNTQPDE----SWYFPTWVVNQVEKGNFLEVIDERVRASASENYQQAKKMVHLALW
   ||.|.| .. |.         |       |... . |  |    ||..    |                            .      ..|  . ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------F--VCCPDEMYQIMKQ

CIQDNADSRPSMRTIVEVL
| . ....||....|.| .
CWHEDPEDRPTFSEIHECF
Kinase IRAKm_o-1.AA TK 740-762 26 0.000101 10.92 In-house 464-486 (486) Show / Hide 
Range on Protein: 740-762
Range on HMM: 464-486/486
Sequence Identity: 26% (6 aa)

LALWCIQDNADSRPSMRTIVEVL
| . | . ... ||......| |
LMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAKm_o-1.AA TK-Unique 744-762 42 0.000161 11.64 In-house 276-294 (294) Show / Hide 
Range on Protein: 744-762
Range on HMM: 276-294/294
Sequence Identity: 42% (8 aa)

CIQDNADSRPSMRTIVEVL
|.|.....||| |.|. .|
CWQWEPEERPSFRQIKHRL
Kinase IRAKm_o-1.AA MLK 744-762 42 0.000269 10.96 In-house 273-291 (291) Show / Hide 
Range on Protein: 744-762
Range on HMM: 273-291/291
Sequence Identity: 42% (8 aa)

CIQDNADSRPSMRTIVEVL
| .... .|||.| ||. |
CWNQDPHKRPSFRQIVQHL
Kinase IRAKm_o-1.AA LISK 740-762 34 0.003504 5.96 In-house 274-296 (296) Show / Hide 
Range on Protein: 740-762
Range on HMM: 274-296/296
Sequence Identity: 34% (8 aa)

LALWCIQDNADSRPSMRTIVEVL
|...|.  . ..|||  .||..|
LCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAKm_o-1.AA Dicty4-Unclassified 740-762 34 0.01106 4.97 In-house 241-263 (263) Show / Hide 
Range on Protein: 740-762
Range on HMM: 241-263/263
Sequence Identity: 34% (8 aa)

LALWCIQDNADSRPSMRTIVEVL
|  ||  .    ||.|  |.. |
LIKWCWHNDPNKRPTMNQIIQYL
Kinase IRAKm_o-1.AA IRAK 734-762 27 0.027514 4.11 In-house 289-317 (317) Show / Hide 
Range on Protein: 734-762
Range on HMM: 289-317/317
Sequence Identity: 27% (8 aa)

AKKMVHLALWCIQDNADSRPSMRTIVEVL
.|.|  .|. |    |  |..|.  .. |
EKEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAKm_o-1.AA Pkinase_Tyr 742-762 28 0.070727 6.98 Pfam 250-270 (270) Show / Hide 
Range on Protein: 742-762
Range on HMM: 250-270/270
Sequence Identity: 28% (6 aa)

LWCIQDNADSRPSMRTIVEVL
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KQCWHYDPEDRPTFSEIHEQL
Kinase IRAKm_o-1.AA TKL-Unique 744-762 31 0.132501 1.65 In-house 272-290 (290) Show / Hide 
Range on Protein: 744-762
Range on HMM: 272-290/290
Sequence Identity: 31% (6 aa)

CIQDNADSRPSMRTIVEVL
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CWHHDPSQRPSFDEIIHRL