Gene IRAKm_q-1 (S.moellendorffii)

IRAKm_q-1

Species: S.moellendorffii
Alias: IRAKm_q-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKm

Sequence

Name Sequence Type Origin Length Description Download
IRAKm_q-1.AA Protein None 252 None Fasta, JSON
IRAKm_q-1.NA RNA None 759 None Fasta, JSON
IRAKm_q-1.kin_dom Protein Kinase Domain None 124 None Fasta, JSON

Protein domain

Protein domains of IRAKm_q-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAKm_q-1.AA TKL 1-234 22 3.5e-41 143.15 In-house 82-364 (364) Show / Hide 
Range on Protein: 1-234
Range on HMM: 82-364/364
Sequence Identity: 22% (70 aa)

ISHVNIVKLCGFCIEGGT------------QWLLVYEFMPNGSLDKWLFEETSENVWLSWQQRIDIALGTAQGLVYLHE----ECRES--ILHLDIKPQN
..| |||.. |.|....             |  .|.|..|.|||   |           |.||...||..|.|. |||      |.    |.| |.|..|
LRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKN

ILLDTEFV--------------AKVADFGMAKLL-----VNRNETQVM-----------TTMWG-TPGYMAPEWLT----------------HFMATKRC
||.|  .               .|..||| .. .      |...| .|           | . . ||..|||| |                 .| ....|
ILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKC

DVDCYGKVLLELIGGHRNIDFLKAVNSGDNTQPDESWYFPTWVVNQVEKGNFLEVIDERVRANA----------HENYYQAKKMVHLALWCIQDNADARP
||  .| || |.. . |               | .   ....... ...  |  |.|.. |               . .  . |  |. .| . ....||
DVYSFGIVLWEILTRCR---------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRP

SMRTIVEVL
|. .|.. |
SFQEILKRL
Kinase IRAKm_q-1.AA Pkinase 2-137 27 1.4e-33 119.79 Pfam 58-195 (293) Show / Hide 
Range on Protein: 2-137
Range on HMM: 58-195/293
Sequence Identity: 27% (41 aa)

SHVNIVKLCGFCIEGGTQWLLVYEFMPNG----SLDKWLFEETSENVWL--SWQQRIDIALGTAQGLVYLHEECRESILHLDIKPQNILLDTEFVA----
.| |||.| ... . ..   .| |....|    .|  ..    ... ..  |... ..... ...|| |.|..   .|.| |.||.|||.| . .     
NHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACV

KVADFGMAKLLVNRNETQVMTTMWGTPGYMAPEWLT-HFMATKRCDV
|..||| ||..      . |||  |||.|||||..  . . ....|.
KICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM
Kinase IRAKm_q-1.AA IRAK 3-155 38 1.6e-31 109.08 In-house 62-225 (317) Show / Hide 
Range on Protein: 3-155
Range on HMM: 62-225/317
Sequence Identity: 38% (64 aa)

HVNIVKLCGFCIEGGTQWLLVYEFMPNGSLDKWLFEETSENVW--LSWQQRIDIALGTAQGLVYLHEEC-RESILHLDIKPQNILLDTEFVAKVADFGMA
| ||| | |.|.|.. .  |||..||||||   |   .  .    |||.||..|..||| |. .||.     .| | |||. |||||  |..| .|||..
HPNIVPLYGYCTERQ-CHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLH

KLL---VNRNETQV---MT-TMWGTPGYMAPEWLT--HFMATKRCDVDCYGKVLLELIGGHRNID
       ..  . .   || .  ||  ||.|| ..      ||. ||   | ||||.. | |  .
RFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAKm_q-1.AA TKL-Unique 3-152 29 3.2e-30 103.84 In-house 55-226 (290) Show / Hide 
Range on Protein: 3-152
Range on HMM: 55-226/290
Sequence Identity: 29% (51 aa)

HVNIVKLCGFCIE---GGTQWLLVYEFMPNGSLDKWLF------EETSENVWLSWQQRIDIALGTAQGLVYLHEECRESILHLDIKPQNILLDTE-----
| |||.. |.|.       .. .| |..| |||.. |          ..|  |..|||...|.  |||. ||| .    |.|.|.|..|.|.| .     
HPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAE

FVAKVADFGMAKLLVNRNETQVM-------TTMWGTPGYMAPEWLTH--FMATKRCDVDCYGKVLLELIGGHR
. .|..||| .|.. ..|.. .        .|  |.. .|||| |.   .. .. .||  .| || |.. ...
WNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKI
Kinase IRAKm_q-1.AA Dicty4 1-124 30 1.2e-26 86.03 In-house 55-187 (277) Show / Hide 
Range on Protein: 1-124
Range on HMM: 55-187/277
Sequence Identity: 30% (42 aa)

ISHVNIVKLCGFCI----EGGTQWLLVYEFMPNGSLDKWLFE---ETSENVWLSWQQRID---IALGTAQGLVYLHE-ECRESILHLDIKPQNILLDTEF
|.| ||... | |.    . |.  . | |.|| |.| . |     |  ... |.|  ..    .|. .|.|. .||.  ..  |.|.|.|. |.| |  .
IRHPNICLFMGACTAPRSHPGK-MCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNW

VAKVADFGMAKLLVNRNETQV-MTTMWGTPGYMAPE
..||.||| ...     . .  ..|. |||..||||
RVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPE
Kinase IRAKm_q-1.AA MLK 1-137 26 3.3e-25 84.49 In-house 62-219 (291) Show / Hide 
Range on Protein: 1-137
Range on HMM: 62-219/291
Sequence Identity: 26% (42 aa)

ISHVN----IVKLCGFCIEGGTQWLLVYEFMPNGSLDKWLFEETS----------ENVWLSWQQRIDIALGTAQGLVYLHEECRESILHLDIKPQNILLD
.|| |    |... | |.. . . ..| |....|||   | ...|            .  . .. ...||  |.|. |||.. .  | | |.|..|||.|
LSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILID

------TEFVAKVADFGMAKLLVNRNETQVMTTMWGTPGYMAPEWL---THFMATKRCDV
       . ..|..||| .. . .. ..  |. . ||. .|||| .    . . .. |||
EICHDMHHGTLKICDFGTSRDWHQMCTN--MMSNAGTYAWMAPEVIQQFRCEKYSEKCDV
Kinase IRAKm_q-1.AA Dicty4-Unclassified 1-150 34 7e-25 82.11 In-house 55-204 (263) Show / Hide 
Range on Protein: 1-150
Range on HMM: 55-204/263
Sequence Identity: 34% (54 aa)

ISHVNIVKLCGFCIEG---GTQWLLVYEFMPNGSLDKWLFEETSE-NVWLSWQQ--RIDIALGTAQGLVYLHEECRESILHLDIKPQNILLDTEFVAKVA
|.| | ||. | ||           | |||. | |        || .  ..      | .|.  |||. .||      . | |||  |||.|  | .|.|
IQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHT---RNFIHRDIKSSNILMDKHFNIKIA

DFGMAKLLVNRNETQVMTTMWGTPGYMAPEWLTHFMATKRCDVDCYGKVLLELIGG
|||..    .   .. |||  |||   .|| | |   . . ||  |. .| ||. |
DFGISRVIDF---NFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATG
Kinase IRAKm_q-1.AA STE 1-124 28 1.6e-21 72.89 In-house 88-232 (359) Show / Hide 
Range on Protein: 1-124
Range on HMM: 88-232/359
Sequence Identity: 28% (44 aa)

ISHVNIVKLCGFCIEGG------TQWLLVYEFMPNGSLDKWLFE--ETSEN--------VWLSWQQRIDIALGTAQG-LVYLHEECRESILHLDIKPQNI
. | ||||  | .. .|      ..  .. |.|..||||. . .  .. ..         ... .| . |.  . .| | |||.     | | ||||.||
M-HPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANI

LLDTEFVAKVADFGMAKLLVN--------------RNETQVMTTMWGTPGYMAPE
||     .| .||| .. |..               .  |  .|. ||| .||||
LL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase IRAKm_q-1.AA RIPK 1-124 30 2e-20 66.28 In-house 53-192 (290) Show / Hide 
Range on Protein: 1-124
Range on HMM: 53-192/290
Sequence Identity: 30% (44 aa)

ISHVNIVKLCGFCIEG-----GTQWLLVYEFMPNGSLDKWLFEETS-ENVWLSWQQRIDIALGTAQGLVYLHEECRE-SILHLDIKPQNILLDTEFVAKV
. . .||.. |||..      .    .| |.|.|||| . |  ...  .  . |  |  .   .. |  |||  .    |.|.| ||.|||.| .| .|.
LRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLH--SMNPPIIHRDLKPENILVDNNFHVKI

ADFGMAKLLVNRNETQ-------VMT----TMWGTPGYMAPE
|||| |. .     .|       |        |||  ||.||
ADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPE
Kinase IRAKm_q-1.AA LISK 1-150 29 5.2e-20 61.52 In-house 53-235 (296) Show / Hide 
Range on Protein: 1-150
Range on HMM: 53-235/296
Sequence Identity: 29% (55 aa)

ISHVNIVKLCGFCIEGGTQWLLVYEFMPNGSLDKWLFEETSENVWLSWQQRIDIALGTAQGLVYLHEECRESILHLDIKPQNILLDTE----FVAKVADF
..| |||.  | | .   |  .| |..  | |   |. . .  . |.|.||..|||. |.|. |||. .   |.| | | .|.|...     . .||.||
LRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDF

GMAKLLVNRNET---------------------------------QVMTTMWGTPGYMAPEWLTHFMATKRCDVDCYGKVLLELIGG
| |.... .|                                   . | |. |||  |||| |.    . .|||  .| ||.|.|..
GFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM-TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITR
Kinase IRAKm_q-1.AA TK-Unique 3-147 25 1.8e-17 56.93 In-house 63-232 (294) Show / Hide 
Range on Protein: 3-147
Range on HMM: 63-232/294
Sequence Identity: 25% (45 aa)

HVNIVKLCGFCIEGGTQWLLVYEFMPNGSLDKWLF----------------------EETSENVWLSWQQRIDIALGTAQGLVYLHEECRESILHLDIKP
| |||...| |.. . .|....|..|.|.|.. |                       ... ..  .| .. . .| . |.|. ||..  |. | | |.  
HPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLAS-QRKKIVHRDLCA

QNILLDTEFVAKVADFGMAK------LLVNRNETQVMTTMWGTPGYMAPEWLT--HFMA-TKRCDVDCYGKVLLEL
 |.||   .|.|..|||||.       ...  . . .  .|     |||| |   | |. | . || ..| .. |.
RNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRW-----MAPESLKCYHGMYHTTKSDVWSFGVLMWEI
Kinase IRAKm_q-1.AA Pkinase_Tyr 1-102 29 2.6e-14 49.12 Pfam 60-161 (270) Show / Hide 
Range on Protein: 1-102
Range on HMM: 60-161/270
Sequence Identity: 29% (31 aa)

I-SHVNIVKLCGFCI-EGGT-QWLLVYEFMPNGSLDKWLFEETSENVWLSWQQRIDIALGTAQGLVYLHEECRESILHLDIKPQNILLDTEFVAKVADFG
. .| |||.| | |. .|.  |...| |.||.|.|.. | .  ...  |. .. .....  |.|. ||..     . | |.   |.|.. ..|.|..|||
LGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFG

MAKLL
.|...
LARDI
Kinase IRAKm_q-1.AA S_TKc 1-234 18 1.4e-11 -7.18 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-234
Range on HMM: 19-231/231
Sequence Identity: 18% (50 aa)

ISHV--------------------------NIVKLCGFCIEGGTQWLLVYEFMPN--GSLDKWLFEETSEN--VWLSWQQRIDIALGTAQGLVYLHEECR
. .                           ||||| ... .  .   .| |....  |.| . . .  ..   ....  .   ..  ....| |.|.   
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG-

ESILHLDIKPQNILLDTEFVAKVADFGMAKLLVNRNETQVMTTMWGTPGYMAPEWLTHFMATK-RCDVDCYGKVLLELIGGHR---NIDFLKAVNSGDNT
  |.| |.||.|||||.  . |..|||.|..|         ||. ||| ||||| |     .| .||.   | .| |.. |     ... .  .      
--IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG----

QPDESWYFPTWVVNQVEKGNFLEVIDERVRANAHENYYQAKKMVHLALWCIQDNADARPSMRTIVE---------VL
                                        . . ..   | | . . ||.   . .          .
---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKm_q-1.AA TyrKc 1-234 16 2.9e-11 -40.44 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-234
Range on HMM: 1-280/280
Sequence Identity: 16% (53 aa)

I------------------------------------------------SHVNIVKLCGFCIEGG------TQWLLVYEFMPNGSLDKWLFEETSENVWL
|                                                .| |||.| | |...|       . ..| |.||.|.|.. | .   .   |
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---L

SWQQRIDIALGTAQGLVYLHEECRESILHLDIKPQNILLDTEFVAKVADFGMAKLLVNR----NETQVMTTMW--GTPG-----YMAPEWLTHFMATKRC
.... .....  |.|  |||.     . | |.   |.|.. ....|..|||... . .      .... ...   |. .      |||| . . . |   
CMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVDCYGKVLLELI-------GG-----HRNIDFLKAVNSG-DNTQPDE----SWYFPTWVVNQVEKGNFLEVIDERVRANAHENYYQAKKMVHLALWCIQ
||  .| .. |.         |       |.. .. | .|    ||..    |                                   ..|  . ..| .
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------F--VCCPDEMYQIMKQCWH

DNADARPSMRTIVEVL
 ... ||....|.| .
EDPEDRPTFSEIHECF
Kinase IRAKm_q-1.AA TK-Unique 216-234 42 0.000236 11.06 In-house 276-294 (294) Show / Hide 
Range on Protein: 216-234
Range on HMM: 276-294/294
Sequence Identity: 42% (8 aa)

CIQDNADARPSMRTIVEVL
|.|.... ||| |.|. .|
CWQWEPEERPSFRQIKHRL
Kinase IRAKm_q-1.AA MLK 216-234 42 0.001065 8.86 In-house 273-291 (291) Show / Hide 
Range on Protein: 216-234
Range on HMM: 273-291/291
Sequence Identity: 42% (8 aa)

CIQDNADARPSMRTIVEVL
| ....  |||.| ||. |
CWNQDPHKRPSFRQIVQHL
Kinase IRAKm_q-1.AA Dicty4-Unclassified 212-234 34 0.011207 4.95 In-house 241-263 (263) Show / Hide 
Range on Protein: 212-234
Range on HMM: 241-263/263
Sequence Identity: 34% (8 aa)

LALWCIQDNADARPSMRTIVEVL
|  ||  .    ||.|  |.. |
LIKWCWHNDPNKRPTMNQIIQYL
Kinase IRAKm_q-1.AA LISK 212-234 34 0.013274 4.05 In-house 274-296 (296) Show / Hide 
Range on Protein: 212-234
Range on HMM: 274-296/296
Sequence Identity: 34% (8 aa)

LALWCIQDNADARPSMRTIVEVL
|...|.  . . |||  .||..|
LCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAKm_q-1.AA IRAK 206-234 27 0.030293 3.96 In-house 289-317 (317) Show / Hide 
Range on Protein: 206-234
Range on HMM: 289-317/317
Sequence Identity: 27% (8 aa)

AKKMVHLALWCIQDNADARPSMRTIVEVL
.|.|  .|. |    |  |..|.  .. |
EKEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAKm_q-1.AA Pkinase_Tyr 214-234 28 0.116973 6.24 Pfam 250-270 (270) Show / Hide 
Range on Protein: 214-234
Range on HMM: 250-270/270
Sequence Identity: 28% (6 aa)

LWCIQDNADARPSMRTIVEVL
. | . ... ||... |.| |
KQCWHYDPEDRPTFSEIHEQL
Kinase IRAKm_q-1.AA TKL-Unique 216-234 31 0.142238 1.54 In-house 272-290 (290) Show / Hide 
Range on Protein: 216-234
Range on HMM: 272-290/290
Sequence Identity: 31% (6 aa)

CIQDNADARPSMRTIVEVL
|  .. . |||  .|.. |
CWHHDPSQRPSFDEIIHRL