Gene IRAKj_a-2 (S.moellendorffii)

IRAKj_a-2

Species: S.moellendorffii
Alias: IRAKj_a-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKj

Sequence

Name Sequence Type Origin Length Description Download
IRAKj_a-2.AA Protein None 959 None Fasta, JSON
IRAKj_a-2.NA RNA None 2880 None Fasta, JSON
IRAKj_a-2.kin_dom Protein Kinase Domain None 204 None Fasta, JSON

Protein domain

Protein domains of IRAKj_a-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 IRAKj_a-2.AA LRRNT_2 28-67 22 3e-06 23.04 Pfam 1-46 (46) Show / Hide 
Range on Protein: 28-67
Range on HMM: 1-46/46
Sequence Identity: 22% (11 aa)

DSAELQVLQNFLKGVKN-PA---LLDSWT----GSDPCGSNWKHIKCQ
.. ..| |. | ... . .     | ||.    .||.|   |. . | 
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCS--WTGVTCD
LRR_1 IRAKj_a-2.AA LRR_1 94-115 37 0.001022 17.35 Pfam 1-26 (26) Show / Hide 
Range on Protein: 94-115
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLENLQLQG-N--GFTGSLPS--LSGL
||. | |.| |   .||..|.  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_a-2.AA LRR_1 117-139 37 0.081328 10.61 Pfam 1-26 (26) Show / Hide 
Range on Protein: 117-139
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

QLQTALLSG-N--SF-DTIPGDFFTGL
.||.  ||| |  .. ..|| . | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_a-2.AA LRR_1 141-168 18 1.219747 6.44 Pfam 1-26 (26) Show / Hide 
Range on Protein: 141-168
Range on HMM: 1-26/26
Sequence Identity: 18% (6 aa)

ALTEIYLDD-N--PLNKSSGGWMLPAE-IQNS
 |....|.. |  .| ..     .| . . | 
NLQHLDLSGCNCCNLTGH-----IPPSCF-NL
LRR_1 IRAKj_a-2.AA LRR_1 170-192 22 49.310839 0.74 Pfam 1-26 (26) Show / Hide 
Range on Protein: 170-192
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

LLSTLSITN-T--SLGGSIPGF-LGQM
 | .|.. . .  .| |.||   . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_a-2.AA LRR_1 194-216 29 0.007263 14.33 Pfam 1-26 (26) Show / Hide 
Range on Protein: 194-216
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLKVLNVAY-N--RISGGIPSS-FGSS
.|..|.. . |  ...| ||.| | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_a-2.AA LRR_1 243-265 25 0.051286 11.32 Pfam 1-26 (26) Show / Hide 
Range on Protein: 243-265
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLRVLWLHV-N--RFSGSIPDG-LGEA
.|..| |   |  ...|.||.. .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_a-2.AA LRR_1 267-289 51 3.1e-05 22.73 Pfam 1-26 (26) Show / Hide 
Range on Protein: 267-289
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

SLQELKLND-N--QLTGTIPPS-LANL
.||.| |.. |  .|||.|||| . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_a-2.AA LRR_1 291-312 25 51.934567 0.66 Pfam 1-26 (26) Show / Hide 
Range on Protein: 291-312
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

ALKNFTVKN-N--LLVGEIPV--FKDT
 |.   . . |   |.|.||   |   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRRNT_2 IRAKj_a-2.AA LRRNT_2 331-380 24 6.5e-05 18.87 Pfam 1-46 (46) Show / Hide 
Range on Protein: 331-380
Range on HMM: 1-46/46
Sequence Identity: 24% (14 aa)

CARDVTALLHFLAGVGY--P-DSLTSSWIGN----DPCGTSGSNGSSGSAWLGISCG
 . |. ||| | ...    | ..  |||  .    |.|            | |..| 
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCS-----------WTGVTCD
LRR_1 IRAKj_a-2.AA LRR_1 388-410 22 0.428767 8.05 Pfam 1-26 (26) Show / Hide 
Range on Protein: 388-410
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

NVTVINLAS-S--QLNGTLSAA-LGNL
| ....| .    .| |...   . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_a-2.AA LRR_1 412-434 40 0.000814 17.7 Pfam 1-26 (26) Show / Hide 
Range on Protein: 412-434
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

TLTTLRLSD-N--KLEGLIPES-LAKL
.|..| ||. |  .|.| ||.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_a-2.AA LRR_1 436-457 28 0.749477 7.19 Pfam 1-26 (26) Show / Hide 
Range on Protein: 436-457
Range on HMM: 1-26/26
Sequence Identity: 28% (8 aa)

SLQSVDLSN-N--LFS-APVPA--FPSS
.||. |||. |   ..   .|   | . 
NLQHLDLSGCNCCNLTGH-IPPSCF-NL
Kinase IRAKj_a-2.AA IRAK 611-887 27 3.4e-66 226.22 In-house 1-317 (317) Show / Hide 
Range on Protein: 611-887
Range on HMM: 1-317/317
Sequence Identity: 27% (89 aa)

FSEATILGRGGFGVVYKGVLDDGT-AIAVKR-MESNCVVSNKGLGEFQA---EIAVLTKVRHRHLVALLGYCIEGNEKMLVYEFMPQGTLSQHLFEAAKC
|...  .| ||||.||.|...  |   |||. .| ...  |.   .||.   |. |... || ..|.|.|||.|. .  |||..|| |.|   | .. . 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRL-WCQDG

GYPP--LDWKQRLSVALDVARGMEYLHGLA-HRSFIHRDLKPSNILLGDDLRAKVSDFGLVK---LAPEGKYSVE-----TRLAGTFGYLAPEYAV--TG
  ||  | | ||.|...  |.| ..|| .    ..||.| |..|||| ... .| .||||.     |.. ....       .. ||  |..||.    .|
QCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQG

RVTTKADVFSFGVVLMELITGR-RALDE-TQAEENMHLVTWFRRSTA---------------------NKE-GVRKLIDPAIESDDNFASISVVAELAGH
. |.| ||.|||.||.|..||. ...|. .  .  . |.     ...                     ..   . |.||. ... .. ..  . . .|. 
QLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPP-NMEKEMCQCACC

CTAREPYQRPDMGHAVNVL
|...    |.||  ... |
CGHHRANRRCDMAWVMQQL
Kinase IRAKj_a-2.AA TKL 617-887 22 1.3e-63 217.64 In-house 1-364 (364) Show / Hide 
Range on Protein: 617-887
Range on HMM: 1-364/364
Sequence Identity: 22% (84 aa)

LGRGGFGVVYKGVLDD---------GTAIAVKRMES-NCVVSNKGL-----------------------GEFQAEIAVLTKVRHRHLVALLGYCIEGNE-
.|.||||.||||..           |. .|||.. | |.  ..| .                        ..  || .. . || ..| ..|||....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KMLVYEFMPQGT-LSQHLFEAAKCGYPPLDWKQRLSVALDVARGMEYLHGLAH-----RSFIHRDLKPSNILLGDDLR----------
             ..|.|..| |. |....            | ||.. |||.||||.|||         .  ||||||..|||. ....          
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPN

----AKVSDFGLVKLAPEGKYSVETR------------------LAGTFGYLAPEY---------AV-------TGRVTTKADVFSFGVVLMELITGRRA
    .|..|||| .   . . .  |                     ||....|||          .|        .  ..|.||.|||.|| |..|..| 
ADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-

LDETQAEENMHLVTWF-----RRSTANKEGVRKLIDPAIES----DDNFASISVVAELAGHCTAREPYQRPDMGHAVNVL
     .....  . ..       . . ..| | .|.|  ..     ..      ...|. .| . .| .|| .   .  |
---PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKj_a-2.AA MLK 611-814 26 1.3e-42 145.61 In-house 1-233 (291) Show / Hide 
Range on Protein: 611-814
Range on HMM: 1-233/291
Sequence Identity: 26% (63 aa)

FSEATILGRGGFGVVYKGVLDDGT----AIAVKRMESNC---VVSNKGLGEFQAEIAVLTKVRHRH----LVALLGYCIE-GNEKMLVYEFMPQGTLSQH
. . ...| |.||.|.||.    .     .|||| ...    ...     .|. |.  | ...|.      ....| |.. ...  .| |... | |.  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LFEAAKCGYP---------PLDWKQRLSVALDVARGMEYLHGLAHRSFIHRDLKPSNILLGD------DLRAKVSDFGLVKLAPEGKYSVETRLAGTFGY
| .| . ...           |  . .. ||..||||.||| .|    ||||||..|||. .      .. .|..|||...   . . .  .  |||. .
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

LAPEY---AVTGRVTTKADVFSFGVVLMELITGR
 |||    .  .... |.||.|.|||| |..|..
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAKj_a-2.AA Pkinase_Tyr 611-812 30 3e-41 140.32 Pfam 1-209 (270) Show / Hide 
Range on Protein: 611-812
Range on HMM: 1-209/270
Sequence Identity: 30% (66 aa)

FSEATILGRGGFGVVYKGVLD-----DGTAIAVKRMESNCVVS-NKGLGEFQAEIAVLTKV-RHRHLVALLGYCIEGNEK---MLVYEFMPQGTLSQHLF
 .    ||.| ||.||||...     ...  ||| .  ..  . |  . .| .|......  .| ..| |.| |..  |    ..| |.|| | |  .| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

EAAKCGYPPLDWKQRLSVALDVARGMEYLHGLAHRSFIHRDLKPSNILLGDDLRAKVSDFGLVKLA-PEGKY-SVETRLAGTFGYLAPEYAVTGRVTTKA
.    . .||. |. |. ....|.|||||.    . .|||||   |.|..... .|..|||| ..  ... |  . .        .|||   .|. ||| 
KHR-EDKQPLTMKDLLQMCWQIAKGMEYLE---SKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKS

DVFSFGVVLMELIT
|| ||||.. |..|
DVWSFGVLMWEIFT
Kinase IRAKj_a-2.AA Pkinase 611-814 25 4.6e-41 146.26 Pfam 1-209 (293) Show / Hide 
Range on Protein: 611-814
Range on HMM: 1-209/293
Sequence Identity: 25% (56 aa)

FSEATILGRGGFGVVYKGVLDDGTA-IAVKRMESNCVVSNKGLGEFQA--EIAVLTKVRHRHLVALLGYCIEGNEKMLVYEFMPQG----TLSQHLFEAA
.    ..|.|.||.|||..  .     |||...     . . . .     ||... ...| . | |.... ....  .| |... |     |. ..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KCGYPPLDWKQRLSVALDVARGMEYLHGLAHRSFIHRDLKPSNILLGDDLRA----KVSDFGLVK-LAPEGKYSVETRLAGTFGYLAPEYAV-TGRVTTK
....  .....  .... ..||.||.|     ..|||||||.|||. ..       |..|||| | .  . ..|  | ..|| .|.|||        ..|
HGCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

ADVFSFGVVLMELITGR
.|..|.|..| |...||
VDMWSCGCILYEMLCGR
Kinase IRAKj_a-2.AA TK 611-812 18 5.3e-41 134.68 In-house 1-389 (486) Show / Hide 
Range on Protein: 611-812
Range on HMM: 1-389/486
Sequence Identity: 18% (72 aa)

FSEATILGRGGFG---VVYKGVLDDG--------------------------TAIAVKRMESNCVVSNK-GLG-------------EFQAEIAVLT--KV
      ||.| ||   .|||| . ..                          |  ||| . . .  | .  .              |. .|....   . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHRHLVALLGYCIEGNEK------------MLVYEFMPQGT----LSQHLFEAAK--------------------------------------CGYP---
.| ..| |.|.| .| .|            |.| |.|| |     | ..| .  .                                      | ..   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

-------------------------------PLDWKQRLSVALDVARGMEYLHGLAHR---SFIHRDLKPSNILLGDDLR-----------AKVSDFG--
                               .|. .|.|  ....|.|||||| .  .    |.||||   |.|.|....           .|..|||  
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LVKLAPEGKYSVETRLAGTFG-------------------------YLAPEYAV---------TGRVTTKADVFSFGVVLMELIT
      | .  ..... . ..  || .                         ..|||            .|. ||| ||.||||.. |. |
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAKj_a-2.AA LRRK 611-819 24 1e-40 141.59 In-house 1-285 (351) Show / Hide 
Range on Protein: 611-819
Range on HMM: 1-285/351
Sequence Identity: 24% (72 aa)

FSEATILGRGGFG-VVYKGVLDD---------------------------GTAIAVKRMESN-------------------------------CVVSNKG
. .   .|||||| .||.. . .                           .. .|.| ..                                    . . 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LGEFQAEIAVLTKVRHRHLVALLGYCIEGNEKMLVYEFMPQGTLSQHLFEAAKCGY----PPLDWKQRLSVALDVARGMEYLHGLAHR-SFIHRDLKPSN
. ||. |.... . .| ..| |.|.||  .  ..| |..|.|.|...|.. .. |     . ..|  .| .||..|.||||||   |. ..||||||. |
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS--HNPPIIHRDLKSPN

ILL-GD-----------DLRAKVSDFGLVK---LAPEGKYSVETRLAGTFGYLAPEYAVTG---RVTTKADVFSFGVVLMELITGR-RALDE
||| .            .  ||..|||.       ..|   |  .. |..|..|||    .     |.|.|..|||..| ||.|.. .. ||
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMG---VAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDE
Kinase IRAKj_a-2.AA Dicty4 611-813 32 2.7e-40 132.22 In-house 1-213 (277) Show / Hide 
Range on Protein: 611-813
Range on HMM: 1-213/277
Sequence Identity: 32% (71 aa)

FSEATILGRGGFGVVYKGVLDDGTAIAVKRM-ESNCVVSNKGLGEFQAEIAVLTKVRHRHLVALLGYCI----EGNEKMLVYEFMPQGTLSQHLFE--AA
     ..|.|.|| ||||    |.. ||| .   | ... . | || .|.. . | || ... ..|.|.    .  . . | |.||.|.|   |    . 
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

KCGYPPLDWKQRLS---VALDVARGMEYLHGLAHRS--FIHRDLKPSNILLGDDLRAKVSDFGLVKLAPEGKYSVE--TRLAGTFGYLAPEYAVTGRVTT
.    .|||  ...    |.|.|||| .||.   .   .||||||..|.|  ...|.||.|||| ..  ...      .  .|| .. |||  .  . . 
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC---CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNE

KADVFSFGVVLMELITG
||||.||| || |. |.
KADVYSFGIVLWEILTR
Kinase IRAKj_a-2.AA TyrKc 611-887 25 3.6e-40 140.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 611-887
Range on HMM: 1-280/280
Sequence Identity: 25% (76 aa)

FSEATILGRGGFGVVYKGVLDDGTAIAVKRMESNCVVSNKGLGEFQAEIAVLTKV--RHRHLVALLGYCIEG-------NEKMLVYEFMPQGTLSQHL-F
 .   .||.| ||.||||...  .  ||| . ...      . .|  |. ...|.  .| ..|.|.|.|...          |.| |.|| | | ..|  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

EAAKCGYPPLDWKQRLSVALDVARGMEYLHGLAHRSFIHRDLKPSNILLGDDLRAKVSDFGLVKLAPEG--------KYSV----ETRLAGTFGYLAPEY
   |     | .|. || ....|.||||||      .|||||   |.|.|.....|.||||| .   ..         |..     ..       .||| 
HRPK-----LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

AVTGRVTTKADVFSFGVVLMELITGRRALDETQAEENMHLVTWFRRSTANKEGVRKLID--PAIESDDNFASISVVAELAGHCTAREPYQRPDMGHAVNV
  .|. ||| ||.||||.. |. |      . .... |   .  ..   . .  ..  .  | . .    ..  .   .   | ...| .|| .   .  
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYP-MSF--VCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase IRAKj_a-2.AA S_TKc 611-891 21 1.1e-39 139.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 611-891
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

FSEATILGRGGFGVVYKGVLDD-GTAIAVKRMESNCVVSNKGLGEFQAEIAVLTKVRHRHLVALLGYCIEGNEKMLVYEFMPQ--GTLSQHLFEAAKCGY
.    ..|.|.||.|||..  . |   |.|..             .. ||..| | .| ..| |.... . ..  .| |....  |.| ... .  . |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

P-PLDWKQRLSVALDVARGMEYLHGLAHRSFIHRDLKPSNILLGDDLRAKVSDFGLVKLAPEGKYSVETRLAGTFGYLAPEYAVTGRVTT-KADVFSFGV
. |..  .  ...  .....||.|    . .|||||||.|||| .  . |..|||| ..         | . ||  |.|||       .. |.|. |.|.
RFPFPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VLMELITGRRALDETQAEENMHLVTWFRRSTANKEGVRKLIDPAIESDDNFASISVVAELAGHCTAREPYQRPDMGHAVN-----VLSPLV
.| |...|.   .  | .. ....                            | ..   .  .|  ..| .||    | .      . | .
ILYEMLCGYPPFP--QMQMMFKKIG---------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKj_a-2.AA TKL-Unique 614-813 31 4.4e-38 131.94 In-house 2-224 (290) Show / Hide 
Range on Protein: 614-813
Range on HMM: 2-224/290
Sequence Identity: 31% (71 aa)

ATILGRGGFGVVYKGVLDDGTAIAVKRMESNCVVSNKGLGEFQAEIAVLTKVR-HRHLVALLGYCI----EGNEKMLVYEFMPQGTLSQHLFE-------
   .|.||.|.||||.   |. .|.|. . |  .||. . ||  |. .. | . |  .| . |||.      ..  .| |..| |.|  .|         
WNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-AAKCGYPPLDWKQRLSVALDVARGMEYLHGLAHRSFIHRDLKPSNILLGDD-----LRAKVSDFGLVKLAP---EGKYSVE-----TRLAGTFGYLAPE
 . .|   .|...||.. |.|.|.||.||| .     ||||||.||.|.  .     ...|..||||.|..    .....       .   |.| ..|||
NNNNC---KLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

YAVT--GRVTTKADVFSFGVVLMELITG
         ..|.||.|||.|| |..|.
VLRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKj_a-2.AA UTK 617-813 27 1.7e-35 118.89 In-house 7-236 (296) Show / Hide 
Range on Protein: 617-813
Range on HMM: 7-236/296
Sequence Identity: 27% (65 aa)

LGRGGFGVVYKGVLDDGT------AIAVKRMESNCVVSNKGLG--EFQAEIA---VLTKVR-HRHLVALLGYCIEGNEKMLVYEFMPQGTLSQHLFEAAK
||.| ||.|.|. ... .      . |||   .  .   .  .  .|  | .   .. ... |.... |.|.|  .   |.|.|.|..| |.. |  ...
LGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRP

-CGYPPLDWK--QRLSVALDVARGMEYLHGLAHRSFIHRDLKPSNILLGDD-------LRAKVSDFG---LVKLAP---------EGKYSVET-RLAGTF
 .. .|.  .  |||. |.|.||||.|||.   . |.||||   |.|....       . .|..|||   . ....         |  |.  . . . ..
TPPACPHWLTLHQRLCMAWDIARGMQYLHS---CGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPI

GYLAPEYAVTG-RVTTKADVFSFGVVLMELITG
   |||  . . | ||| ||.|||||..|. |.
RWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW
Kinase IRAKj_a-2.AA Src 611-814 33 1e-33 111.89 In-house 1-198 (255) Show / Hide 
Range on Protein: 611-814
Range on HMM: 1-198/255
Sequence Identity: 33% (69 aa)

FSEATILGRGGFGVVYKGVLDDGTAIAVKRMESNCVVSNKGLGEFQAEIAVLTKVRHRHLVALLGYCIEGNEKMLVYEFMPQGTLSQHLFEAAKCGYPPL
.     ||.| || |..|. .. |  ||| . .    |..    |..|. ...|.|| .||.|.  | ..     | |.| .| | . | .  ....  |
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGT-MSPE---AFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH--L

DWKQRLSVALDVARGMEYLHGLAHRSFIHRDLKPSNILLGDDLRAKVSDFGLVKLAP--EGKYSVETRLAGTFGYLAPEYAVTGRVTTKADVFSFGVVLM
  .| .. |  ||.||.|   |  . .|||||   |.| |... .|| |||| .|    .  |. ..         ||| .  || |.|.|| |||. |.
HLPQLIDMAAQVAEGMAY---LESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLT

ELIT-GR
|..| ||
EIVTYGR
Kinase IRAKj_a-2.AA LISK 616-762 33 4.6e-29 91.4 In-house 1-151 (296) Show / Hide 
Range on Protein: 616-762
Range on HMM: 1-151/296
Sequence Identity: 33% (53 aa)

ILGRGGFGVVYKGVLD-DGTAIAVKRMES--NCVVSNKGLGEFQAEIAVLTKVRHRHLVALLGYCIE-GNEKMLVYEFMPQGTLSQHLF-EAA-KCGYPP
..|.|.|| |||| .  .|. .|.|  ..  | .  .  .  .. |.... . ||.. |   | | .   . ..| |..  |.| | |. ..  |    |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKI---P

LDWKQRLSVALDVARGMEYLHGLAHRSFIHRDLKPSNILLG----DDLRAKVSDFGL
| |.||.. |||.|.||.|||    .  ||||||  |.|..    .. |.|| |||.
LPWPQRVKIALDIACGMSYLH---SMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGF
Kinase IRAKj_a-2.AA LISK 795-816 54 1e-08 24.23 In-house 217-238 (296) Show / Hide 
Range on Protein: 795-816
Range on HMM: 217-238/296
Sequence Identity: 54% (12 aa)

TTKADVFSFGVVLMELITGRRA
....||||||.|| |.||...|
DESCDVFSFGIVLCEIITRVKA
Kinase IRAKj_a-2.AA TK 861-887 22 0.0939 0.79 In-house 460-486 (486) Show / Hide 
Range on Protein: 861-887
Range on HMM: 460-486/486
Sequence Identity: 22% (6 aa)

VVAELAGHCTAREPYQRPDMGHAVNVL
....|   | ...| .||..   .. |
EYYDLMQQCWHYDPEDRPTFSQLHEQL