Gene IRAK-Un_ap-2 (S.moellendorffii)

IRAK-Un_ap-2

Species: S.moellendorffii
Alias: IRAK-Un_ap-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_ap-2.AA Protein None 380 None Fasta, JSON
IRAK-Un_ap-2.NA RNA None 1143 None Fasta, JSON
IRAK-Un_ap-2.kin_dom Protein Kinase Domain None 202 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_ap-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_ap-2.AA TKL 79-275 22 3.4e-52 179.73 In-house 1-287 (364) Show / Hide 
Range on Protein: 79-275
Range on HMM: 1-287/364
Sequence Identity: 22% (66 aa)

VGRGGFASVYKGVIDN----------HFVAVKYLTS-------------------------SDLSDKARRDFENEVSTICLLQHKNVVKLFGFCSEKEH-
.|.|||. ||||.  .            |||| . |                         .. . ..|  .|.|.  .  |.| |.|.. |.| . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KLTVCEFIENGNLSDALFRSPDKGLELNWTARYNICVGVAQGLAYLHGET---SQAT--IVHRDIKALSILLASNLE-----------
               | |....|.| . |           |  | ... ..|.|..||| ..   .. .  |.|||.|   ||. .|..           
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

---AKISDFGLARLIQEDRSYINTR------------------ATGTVGYLAPEYAL----------------SGQLTEKADVYSFEILVLEILSGRI
   .||.||||.| .... .   |                     || ...|||                   ... .||.||||| |.  |||....
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR
Kinase IRAK-Un_ap-2.AA IRAK 73-274 36 1.5e-45 157.61 In-house 1-221 (317) Show / Hide 
Range on Protein: 73-274
Range on HMM: 1-221/317
Sequence Identity: 36% (80 aa)

FHKDNLVGRGGFASVYKGVIDNHF--VAVKYLTSSDLS--DKARRDFEN---EVSTICLLQHKNVVKLFGFCSEKEHKLTVCEFIENGNLSDALF-RSPD
|||||. | |||. ||.|...|    .||| | .   .  .. .. |     |. . |...|.|.| | |.|.| .    | ... || | | |  . ..
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

KGL-ELNWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALSILLASNLEAKISDFGLARL-----IQEDRSY---INTRATGTVGYLAPEYAL--SGQ
  .  | |  |  || | | |. .||   .   | |.|||   |||  ....||.||||.|        |. .|   .  .  ||  |..||.    .||
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTEKADVYSFEILVLEILSGR
|| | ||||| | .||.|.|.
LTKKTDVYSFGIVLLEVLTGC
Kinase IRAK-Un_ap-2.AA TKL-Unique 77-275 30 5.4e-41 142.32 In-house 3-226 (290) Show / Hide 
Range on Protein: 77-275
Range on HMM: 3-226/290
Sequence Identity: 30% (70 aa)

NLVGRGGFASVYKGVIDNHFVAVKYLT-SSDLSDKARRDFENEVSTICLLQ-HKNVVKLFGFCS----EKEHKLTVCEFIENGNLSDALFR------SPD
|..|.||...||||.     ||.| .   .|.| . ...|||||...  |. |.|.|...|.|        .   |.|... |.| | | .         
NKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

KGLELNWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALSILLASN-----LEAKISDFGLARLIQEDRSYINTRAT--------GTVGYLAPEYALS
. ..||.  |...   .|||. |||  .....| |||.| ...|. .|     . .||.||||...   .   .|.. .        |.  ..|||  |.
NNCKLNMQQRVKMAIDIAQGMYYLH--HCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV-LR

G---QLTEKADVYSFEILVLEILSGRI
.   | .||.||||| | . ||... |
MNFCQYSEKSDVYSFGIVLWEIATRKI
Kinase IRAK-Un_ap-2.AA TK 73-272 17 5.6e-34 110.73 In-house 1-389 (486) Show / Hide 
Range on Protein: 73-272
Range on HMM: 1-389/486
Sequence Identity: 17% (70 aa)

FHKDNLVGRGGFA---SVYKGVIDNH---------------------------FVAVKYLTS-SDLSDKARRD--------------FENEVSTIC--LL
 .  .  |.| |     ||||   ..                            |||| |.. .. |.....|              . .| .  |  |.
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHKNVVKLFGFCSEK------------EHKLTVCEFIENGN----LSDALFRSPDKGLE-----------------------------------------
.|.|.|.|.| |...            |. . | |. ..|.    | | | ....|. .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LNWTARYNICVGVAQGLAYLHGETSQAT---IVHRDIKALSILLASNLE-----------AKISDFG--
                               |.   .  .|. .|.|..|||    .     .||||. |  .|...|.            .||.|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LARLIQEDRSYINTRATGTVG-------------------------YLAPEYALSGQ---------LTEKADVYSFEILVLEILS
      ||| |..|  |  ..  || .                         ..|||  ....          |.| ||.|| .|. ||..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-Un_ap-2.AA MLK 73-275 25 5.3e-33 111.88 In-house 1-234 (291) Show / Hide 
Range on Protein: 73-275
Range on HMM: 1-234/291
Sequence Identity: 25% (60 aa)

FHKDNLVGRGGFASVYKGVIDNHF-----VAVKYLTSSDLSDKAR-----RDFENEVSTICLLQHKN----VVKLFGFCSEKEH-KLTVCEFIENGNLSD
.     .| |.| .|.||.  |       ||||  ...   ||..     .||| |.     |.|.|    .... | |.. ..  . | |..|.| |..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ALFRSPDKGL----------ELNWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALSILLAS------NLEAKISDFGLARLIQEDRSYINTRATGTV
 |   ..|.                   |... .|.|..||| .  . .|.|||.|   ||..       .. .||.|||..| ...      . . ||.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMA-PKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTY

GYLAPEY---ALSGQLTEKADVYSFEILVLEILSGRI
 . |||    . ... .||.||.|. ..  |.|....
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREV
Kinase IRAK-Un_ap-2.AA Dicty4 73-271 29 4.1e-32 104.51 In-house 1-211 (277) Show / Hide 
Range on Protein: 73-271
Range on HMM: 1-211/277
Sequence Identity: 29% (62 aa)

FHKDNLVGRGGFASVYKGVIDNHFVAVKYL--TSSDLSDKARRDFENEVSTICLLQHKNVVKLFGFCS----EKEHKLTVCEFIENGNLSDALFR---SP
  .... |.|.|..||||      |||| |  .  ... .   .| .||.  | ..| |.... | |     ...  . | |.   |||   |       
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

DKGLELNWTARYN---ICVGVAQGLAYLHGETSQATIVHRDIKALSILLASNLEAKISDFGLARLIQEDRSYIN--TRATGTVGYLAPEYALSGQLTEKA
 .  .| |. .     ..  .|.|...||.  .   |.|||.|.  .|   |. .|..||||....... .     . | ||... |||   .   .|||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHC--CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFEILVLEIL
||||| |.  |||
DVYSFGIVLWEIL
Kinase IRAK-Un_ap-2.AA Dicty4-Unclassified 73-273 31 4.2e-32 107.21 In-house 1-204 (263) Show / Hide 
Range on Protein: 73-273
Range on HMM: 1-204/263
Sequence Identity: 31% (67 aa)

FHKDNLVGRGGFASVYKGVIDNHFVAVKYLTSSDLSDKAR----RDFENEVSTICLLQHKNVVKLFGFCSEK-EHKLTVC---EFIENGNLSDALF---R
   |  .|.| |. |.||.     |||| . .   ..|.|     ||  ||    ..|| | ||. | |     || | |   ||.  |||         
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNEN--KFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPS

SPDKGLELNWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALSILLASNLEAKISDFGLARLIQEDRSYINTRATGTVGYLAPEYALSGQLTEKADVY
  .. . |. |    .   .|||...||       ..|||||.  ||.  .  .|| |||..| |  |  .  |   ||.   .||       . |.|||
EQQQPIKLDDTLIIKYAFDIAQGMQHLH----TRNFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESYNQKSDVY

SFEILVLEILSG
|. ..  | . |
SYAMMLYELATG
Kinase IRAK-Un_ap-2.AA Src-Echino1 74-275 34 1.1e-31 106.93 In-house 2-196 (252) Show / Hide 
Range on Protein: 74-275
Range on HMM: 2-196/252
Sequence Identity: 34% (71 aa)

HKDNLVGRGGFASVYKGVI-DNHFVAVKYLTSSDLSDKARRDFENEVSTICLLQHKNVVKLFGFCSEKEHKLTVCEFIENGNLSDALFRSPDKGLELNWT
. |. .|.| .. |.|||   |  |||| |    .|. .   |  |   .  ..|...|...  ||.||    | | ..|||| | | |  .|. ..  |
RMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPAD---FLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKR--GKCKHVKMT

ARYNICVGVAQGLAYLHGETSQATIVHRDIKALSILLASNLEAKISDFGLARLIQEDRSYINTRATGTVGYLAPEYALSGQLTEKADVYSFEILVLEILS
   ..   .| |. ||     .  .||||. |  .|..     || ||||||..|.|    .  |   . . ||| || |. | |.||.|| ||. |.. 
TLIDMGAHIASGMDYLG----SKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVT

-GRI
 ||.
FGRY
Kinase IRAK-Un_ap-2.AA Pkinase 73-274 26 1.7e-31 112.43 Pfam 1-209 (293) Show / Hide 
Range on Protein: 73-274
Range on HMM: 1-209/293
Sequence Identity: 26% (58 aa)

FHKDNLVGRGGFASVYKGV--IDNHFVAVKYLTSSDLSDKARRDFEN--EVSTICLLQHKNVVKLFGFCSEKEHKLTVCEFIENG----NLSDALFRSPD
.|.   .|.|.|..|||..   ... |||| .  .. ... ..   .  |..    |.|.|.|.|.... .| |   | |. |.|     |.| . .  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

KGLEL--NWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALSILLASNLEA----KISDFGLARLIQEDRSYINTRATGTVGYLAPEYAL-SGQLTEK
..  .   .    ...  ...||.|.| .     |.|||.|   ||. .| .     ||.|||||..... ..  .|  .|| .|.|||  . .   . |
RHGCFYFSEWECKFYMYQILRGLEYCHSM----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

ADVYSFEILVLEILSGR
.|..|. ... | |.||
VDMWSCGCILYEMLCGR
Kinase IRAK-Un_ap-2.AA LRRK 73-275 23 5.1e-31 106.96 In-house 1-281 (351) Show / Hide 
Range on Protein: 73-275
Range on HMM: 1-281/351
Sequence Identity: 23% (69 aa)

FHKDNLVGRGGFA-SVYKGVIDN----------------------------HFVAVKYLTS----SDLSD-----------------------------K
. . ...|||||. .||..   .                              ||.| ..     .|  |                             .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTID-NDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCR

ARRDFENEVSTICLLQHKNVVKLFGFCSEKEHKLTVCEFIENGNLSDALFRSPDKGL-----ELNWTARYNICVGVAQGLAYLHGETSQAT--IVHRDIK
| | | .||. .. |.| |.|.|.|||   ..   | |.. .|.|.. |. .   |.     ...|. .. | . .| |..|||     ..  |.||| |
AFREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS----HNPPIIHRDLK

ALSILL-AS-----------NLEAKISDFGLARLIQEDRSYINTRATGTVGYLAPEYALSG---QLTEKADVYSFEILVLEILSGR-I
   |||  |           .  |||.|||. |. | ... .  . .|. |..|||    .   . |||.|.||| ..  |.|... .
SPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHH
Kinase IRAK-Un_ap-2.AA STE 73-274 19 1.2e-29 101.85 In-house 1-265 (359) Show / Hide 
Range on Protein: 73-274
Range on HMM: 1-265/359
Sequence Identity: 19% (53 aa)

FHKDNLVGRGGFASVYKGVID-----------------NHFVAVKYLTSSDLS---------------DKARRDFENEVSTICLLQ--HKNVVKLFGFCS
. .   .|.|.| .|||..                   . ..|.| .  .. .               .. . ....|...   ..  |.|.|| .| . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EK------EHKLTVC-EFIENGNLSDALFR--SPDKGLE----------LNWTARYNICVGVAQG-LAYLHGETSQATIVHRDIKALSILLASNLEAKIS
 .      ...| .| |....| |.| . .  .. |.|            .. |.  ||. . .| |.|||       |.|||||.  |||     .|..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAY--ICRQILKGLLYYLHSHH----IIHRDIKPANILL-----VKLC

DFGLARLIQE---------------DRSYINTRATGTVGYLAPEYALS------GQLTEKADVYSFEILVLEILSGR
|||..  ...               ...  ..  .||  . |||  .       .. ..|.|..|. ....| . |.
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-Un_ap-2.AA Pkinase_Tyr 73-272 30 1.9e-29 100.33 Pfam 1-209 (270) Show / Hide 
Range on Protein: 73-272
Range on HMM: 1-209/270
Sequence Identity: 30% (65 aa)

FHKDNLVGRGGFASVYKGVID------NHFVAVKYLTSSDLSDKA--RRDFENEVSTICLL-QHKNVVKLFGFCS-EKEH--KLTVCEFIENGNLSDALF
 ...   |.| | .||||. .      .  |||| |   . ....  |.|| .|... . | .|.|.|.| | |. ..|.   . | |. ..|.| | | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RS--PDKGLELNWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALSILLASNLEAKISDFGLARLI-QEDRS-YINTRATGTVGYLAPEYALSGQLTE
.   ... | . .    ..|. .|.|..||.       ..|||. |  .|...|. .||.||||||.|  .|   .  . .   .  .|||    |  |.
KHREDKQPLTMKD--LLQMCWQIAKGMEYLESKN----CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

KADVYSFEILVLEILS
| ||.|| .|  ||..
KSDVWSFGVLMWEIFT
Kinase IRAK-Un_ap-2.AA TyrKc 73-348 23 2.4e-22 81.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 73-348
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

FHKDNLVGRGGFASVYKGVIDNHFVAVKYLTSSDLSDKARRDFENEVSTICLL--QHKNVVKLFGFCSEK-------EHKLTVCEFIENGNLSDALFRSP
 ...   |.| |  ||||. .   |||| | ..      |.|| .| .  | |  .|.|.|.|.| |...       |  . | |. ..|.| | | .. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

DKGLELNWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALSILLASNLEAKISDFGLARLIQED------RSYINT----RAT--GTVGYLAPEYALS
.|   |..    ..|. .|.| .|||       ..|||. |  .|...|. .|||||||.| | .|       .|. .     .     .  .|||    
PK---LCMKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

GQLTEKADVYSFEILVLEILSGRISMDFTLSDGDS-----FLLERAWNVFQSGHLLEMIDKRLDVGDERDI---HKMERVFLVALHCTQASGSRRSSMFR
|  |.| ||.|| ..  ||..      .  .            ... .  ..|. ..  .  .    .  .   .  . .. . . | ..  . | ..  
GKFTTKSDVWSFGVCMWEIFT------YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY----P--MSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

VVGML
..  .
IHECF
Kinase IRAK-Un_ap-2.AA S_TKc 73-325 22 4.6e-20 73.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 73-325
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

FHKDNLVGRGGFASVYKGVIDN--HFVAVKYLTSSDLSDKARRDFENEVSTICLLQHKNVVKLFGFCSEKEHKLTVCEFIEN--GNLSDALFRSPDKG--
... ...|.|.|..|||..  .  . ||.| .          .....|..     .|.|.|||.... . .|   | |....  |.| | . . . .|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LELNWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALSILLASNLEAKISDFGLARLIQEDRSYINTRATGTVGYLAPEYALSGQLTE-KADVYSF
  .   ....|  .  ....|.|.|   |.  |.|||.|   ||| .  . ||.||||||..        |   ||  |.|||     . .  |.|..|.
FPFPE-HARFY--MYQICCALEYCH---SH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

EILVLEILSGRISMDFTLSDGDSFLLERAWNVFQSGHLLEMIDKRLDV-----GDERDIHKME-----RVFL
 ... | |.|.   .      .  ....      |  ....|.| |..         .. ..|       ..
GCILYEMLCGYPPFP-----QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF