Gene IRAK-Un_t (S.moellendorffii)

IRAK-Un_t

Species: S.moellendorffii
Alias: IRAK-Un_t
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_t.AA Protein None 812 None Fasta, JSON
IRAK-Un_t.NA RNA None 2439 None Fasta, JSON
IRAK-Un_t.kin_dom Protein Kinase Domain None 150 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_t.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 IRAK-Un_t.AA LRR_1 98-120 25 3.950825 4.63 Pfam 1-26 (26) Show / Hide 
Range on Protein: 98-120
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

ALRLLNATGF--VML-GTLPDW-IGQL
 |. |.  |.  . | |..|.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_t.AA LRR_1 122-147 26 1.251844 6.4 Pfam 1-26 (26) Show / Hide 
Range on Protein: 122-147
Range on HMM: 1-26/26
Sequence Identity: 26% (8 aa)

ALQVLDFSAC---SINGLDGSVPEN-LTGW
 ||.||.| |   .. |    .|.. . . 
NLQHLDLSGCNCCNLTGH---IPPSCF-NL
LRR_1 IRAK-Un_t.AA LRR_1 149-171 33 0.255037 8.85 Pfam 1-26 (26) Show / Hide 
Range on Protein: 149-171
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

TLQELVLGK-N--LLAGELPGA-LQDL
.||.| |.  |   | |..|   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_t.AA LRR_1 173-195 51 0.000284 19.32 Pfam 1-26 (26) Show / Hide 
Range on Protein: 173-195
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

NLTLLDLSL-N--NFTGTIPPG-LASL
||. ||||  |  |.||.|||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_t.AA LRR_1 197-219 37 0.004762 14.98 Pfam 1-26 (26) Show / Hide 
Range on Protein: 197-219
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLQSLDLSN-N--TFYGPLPAA-VSSL
.||.||||. |   . | .|     .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_t.AA LRR_1 221-254 21 4.215854 4.53 Pfam 1-26 (26) Show / Hide 
Range on Protein: 221-254
Range on HMM: 1-26/26
Sequence Identity: 21% (8 aa)

GLLVLNVSD-N--FLNDTVPAGTVAGAILSENCFVNA
 | .|..|. |   | ..          ....|| | 
NLQHLDLSGCNCCNLTGH----------IPPSCF-NL
Kinase IRAK-Un_t.AA TKL 397-673 16 7.9e-24 82.68 In-house 1-364 (364) Show / Hide 
Range on Protein: 397-673
Range on HMM: 1-364/364
Sequence Identity: 16% (66 aa)

IKAGHSGDLYRGVLDG---------GVLVVVKRIEV----------------------------AKMKKDLLTLELEVFGKASHTRLVPLLGHCLEMDE-
|  |..|  |.|.. |         |  |.||.. .                            |.  .. .  |. .  . .|  .|...| |.. .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------LKFLVYKYMPNGDLGQALHKKVVPSPPADILQSLDWITRLKIAIGVAEGLSYLHHECV-----PPLVHRDVQASSILLDDKFE------
             ..|. |.|.|.|   ||                |  |...|...| |..||| .       ||..|||   . ||.|....      
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYM

--------VRLGSLSETREQGGEAQPGLIT---------RLLRLSQTTEQG----------------DQGSA---------VASCAYDVYCFGKVLLELV
        . .. .   |.  .. .   .          . .. ..|  |.                ..  .          .| . ||| || || |..
YNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEIL

TGKLDISGTSDPNADAWLE---WALPLIDRHNKEGIMKLVDPSL--IVDE----DLLEEVWA-MAIVAKLCLHGRASKRPQIRHVLKAL
|...       | .| . .   .. | ..   .  . |   | .  |  .       . ..  |.  .. | .  ..|||    .|| |
TRCR-------PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-Un_t.AA IRAK 391-536 31 3.2e-21 72.05 In-house 1-151 (317) Show / Hide 
Range on Protein: 391-536
Range on HMM: 1-151/317
Sequence Identity: 31% (49 aa)

FSSSNFIKAGHSGDLYRGVLDGGV-LVVVK------RIEVAKMKKDLLT--LELEVFGKASHTRLVPLLGHCLEMDELKFLVYKYMPNGDLGQALHKKVV
|. .| |  |  |. |||....    ..||       ..  .... ...   ||.|  .  |  .|||.| |.| ...  ||| ||||| |   |.    
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCH-CLVYPYMPNGSLEDRLWCQDG

PSPPADILQSLDWITRLKIAIGVAEGLSYLHHEC-VPPLVHRDVQASSILLDDKFE
  ||    . | |..|..|..| | |. .||      |. |.|.  . ||||. |.
QCPP----KPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFT
Kinase IRAK-Un_t.AA TK 391-540 14 1.7e-16 51.07 In-house 1-293 (486) Show / Hide 
Range on Protein: 391-540
Range on HMM: 1-293/486
Sequence Identity: 14% (42 aa)

FSSSNFIKAGHSG---DLYRGVLDGG--------------------------VLVVVKRIEV-AKMKKDLLTL-----------------ELEVFG--KA
    . . .|. |   . |.| . |.                          . | || .   . | ..   .                 |....   . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHTRLVPLLGHCLEMD-----------ELKFLVYKYMPNGD----LGQALHKKVV---------------------------------------------
 |  .| |.|.|.. .           |   .|  |||.||    | . |.|.                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------PSPPADILQ-----------SLDWITRLKIAIGVAEGLSYLHHE----CVPPLVHRDVQASSILLDDKFE-----------VRLG
          | . .| ||            |.  ..| ..  .|.|..|||        . .||||. |  .|....             ....
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIA
Kinase IRAK-Un_t.AA MLK 391-537 20 1.1e-12 40.48 In-house 1-171 (291) Show / Hide 
Range on Protein: 391-537
Range on HMM: 1-171/291
Sequence Identity: 20% (35 aa)

FSSSNFIKAGHSGDLYRGVLDGGV----LVVVKRIE-------VAKMKKDLLTLELEVFGKASHTR----LVPLLGHCLEMDELKFLVYKYMPNGDLGQA
.  . .| .|..|. ..|.  .       | |||..       ..   .. .  | . . . ||       ....| ||.     ..|  |...| |   
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHK-KVVPS------PPADILQSLDWITRLKIAIGVAEGLSYLHHECVPPLVHRDVQASSILLDD-----KFEV
||  .  ..      .  |. ...| .  ...|  .|.|..||| . ..|..|||   . ||.|.     . ..
LHGARSKWMDANHNQK-NDRVYDHDHA--MNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGT
Kinase IRAK-Un_t.AA TK-Unique 391-540 19 1.7e-11 36.03 In-house 1-175 (294) Show / Hide 
Range on Protein: 391-540
Range on HMM: 1-175/294
Sequence Identity: 19% (35 aa)

FSSSNFIKAGHSGDLYRGVLDG---------GVLVVVKRIEVAKMKKDLLTLELEVFGKAS-HTRLVPLLGHCLEMDELKFLVYKYMPNGDLGQALHKKV
.   . |  |  |  .|| . |          |.|.  .... . .|. .. |.... .   |  .| .|| | . ||  .... |.|.|.|   |... 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

---------------VPSPPADILQS-LDWITRLKIAIGVAEGLSYLHH--ECVPPLVHRDVQASSILLDDKFEVRLG
               ....|.. . . ..  . . .|...| |..||.   . .   ||||. |. .|| ..... ..
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI---VHRDLCARNVLLTEDKVCKIC
Kinase IRAK-Un_t.AA Pkinase_Tyr 399-524 24 2.4e-11 39.08 Pfam 9-137 (270) Show / Hide 
Range on Protein: 399-524
Range on HMM: 9-137/270
Sequence Identity: 24% (34 aa)

AGHSGDLYRGVLD-----GGVLVVVKRI--EVAKM---KKDLLTLELEVFGKA-SHTRLVPLLGHCLEMDEL--KFLVYKYMPNGDLGQALHKKVVPSPP
.|. |. |.|...     ... | || .     .    ..|..  |...  .  .|  .| |.| |.. .|    ..|  |||.|||   |.|.      
EGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR-----

ADILQSLDWITRLKIAIGVAEGLSYLHHECVPPLVHRDV
 .  |.|.  . |.... .|.|..||.      ..|||.
-EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDL
Kinase IRAK-Un_t.AA MLK 391-536 27 1.1e-10 31.26 In-house 1-141 (280) Show / Hide 
Range on Protein: 391-536
Range on HMM: 1-141/280
Sequence Identity: 27% (42 aa)

FSSSNFIKAGHSGDLYRGVLDGGVLVVVKRIE------VAKM--KKDLLTLELEVFGKASHTRLVPLLGHCLEMDELKFLVYKYMPNGDLGQALHKKVVP
      | .|  |  ||.. . | .| ||.        ....  . . .  |   |.  .|   . |.| |||  .|  ||  |   | | ...  | . 
LKIKEIIGNGGFGKVYRAQWK-GEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHL-CLVMEYCRGGSLNRVCAGKRI-

SPPADILQSLDWITRLKIAIGVAEGLSYLHHECVPPLVHRDVQASSILLDDKFE
  | ..|   .|      |. .|.|. |||.| . |..|||  .| ||. .| .
--PPHVL--VNW------AVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKIC
Kinase IRAK-Un_t.AA TyrKc 391-673 18 1.2e-10 -50.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 391-673
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

FSSSNFIKAGHSGDLYRGVLDGGVLVVVKRIEVAKMKKDLLTLELEVFGKA--SHTRLVPLLGHCLEM------DELKFLVYKYMPNGDLGQALHKKVVP
 .    .  |. |  |.|...  . | || .   .  .  .  |...  |   .|  .| |.| |..       .|  ..|  |||.||| . |.|.   
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

SPPADILQSLDWITRLKIAIGVAEGLSYLHHECVPPLVHRDVQASSILLDDKFEVRLGSLSETREQGGEAQPGLITRLLRLSQTTEQG-DQGS-------
         | . . |.... .|.| .|||.    ...|||  |  .|..... |. .    .|. . . | |      . .  . .. ..|        
---------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-----ESKDYYRKKEHKGGKTMLPIRW

----AVASCAY----DVYCFGKVLLELVT-GKLDISG-----TSDPNADAWLEWA--LPLIDRHNKEGIMKLVDPSLIVDEDLLEEVWAMAIVAKLCLHG
    .   . .    ||. || .. |. | |.   .|      |.  . ....    .|  . .  . .               .   .|  . | | | 
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS------------FVCCPDEMYQIMKQCWHE

RASKRPQIRHVLKAL
 ...||  . . . .
DPEDRPTFSEIHECF
Kinase IRAK-Un_t.AA LRRK 466-523 35 9.3e-10 30.68 In-house 136-191 (351) Show / Hide 
Range on Protein: 466-523
Range on HMM: 136-191/351
Sequence Identity: 35% (23 aa)

YMPNGDLGQALHKKV------VPSPPADILQSLDWITRLKIAIGVAEGLSYLHHECVPPLVHRD
|.|.||| . ||.|       ..        ...| ..||||. .|.|. || | . ||..|||
YAPHGDLYHFLHNKKQDGFHFMK-------AHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRD
Kinase IRAK-Un_t.AA S_TKc 391-647 15 2.2e-08 -54.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 391-647
Range on HMM: 1-231/231
Sequence Identity: 15% (42 aa)

FSSSNFIKAGHSGDLYRGVLDG-GVLVVVKRIEVAKMKKDLLTLELEVFGKASHTRLVPLLGHCLEMDELKFLVYKYMPN--GDLGQALHKKVVPSPPAD
.   . |  |  |  |...  . | .| .|.|       . .  |...  |  |  .| |.... .  .  ..|  |...  ||| . ..|.  . ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR--

ILQSLDWITRLKIAIGVAEGLSYLHHECVPPLVHRDVQASSILLDDKFEVRLGSLSETREQGGEAQPGLITR------LLRLSQTTEQGDQGSAVASC-A
  . ..  .  ...  ....| |.|   .   .|||.  . ||||.  .. ..     |.          |.      .|                .. .
--FPFPE-HARFYMYQICCALEYCHSHGI---IHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL--------------GYGKCK

YDVYCFGKVLLELVTGKLDISGTSDPNADAWLEWALPLIDRHNKEGIMKLVDPSLIVDED------LLE-------EVWA
 |.. .| .| |...|.   .     . .. ..  .       .|..  ...  | .| .      .|.         | 
CDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG------SPEAKD-FIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase IRAK-Un_t.AA CZAK 497-533 42 2.4e-08 26.58 In-house 107-144 (279) Show / Hide 
Range on Protein: 497-533
Range on HMM: 107-144/279
Sequence Identity: 42% (16 aa)

RLKIAIGVAEGLSYLHHECVP-PLVHRDVQASSILLDD
....|| .|.|  |||    | | .|||   . ||||.
QWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDH
Kinase IRAK-Un_t.AA HH498 497-532 36 2.5e-07 18.89 In-house 123-158 (284) Show / Hide 
Range on Protein: 497-532
Range on HMM: 123-158/284
Sequence Identity: 36% (13 aa)

RLKIAIGVAEGLSYLHHECVPPLVHRDVQASSILLD
.. |.. || |  |||    .| .|||     ||..
KMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIH
Kinase IRAK-Un_t.AA Dicty4-Unclassified 434-542 26 6.4e-07 19.7 In-house 48-153 (263) Show / Hide 
Range on Protein: 434-542
Range on HMM: 48-153/263
Sequence Identity: 26% (30 aa)

ELEVFGKASHTRLVPLLGHCLEM---DELKFLVYKYMPNGDLGQALHKKVVPSPPADILQSLDWIT--RLKIAIGVAEGLSYLHHECVPPLVHRDVQASS
| |. |  .|  || . | |.           |   |. | |    | |     |..  |..       .|.|. .| |. .||      ..|||. .| 
EVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSK-----PSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSN

ILLDDKFEVRLGSL
||.|  | .. . .
ILMDKHFNIKIADF
Kinase IRAK-Un_t.AA IRAK 647-673 33 0.000496 10.37 In-house 291-317 (317) Show / Hide 
Range on Protein: 647-673
Range on HMM: 291-317/317
Sequence Identity: 33% (9 aa)

AMAIVAKLCLHGRASKRPQIRHVLKAL
.|. .|  |.|.|| .|. .. |.. |
EMCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAK-Un_t.AA IRAK 582-596 73 0.00808 6.02 In-house 206-220 (317) Show / Hide 
Range on Protein: 582-596
Range on HMM: 206-220/317
Sequence Identity: 73% (11 aa)

DVYCFGKVLLELVTG
||| || ||||..||
DVYSFGIVLLEVLTG
Kinase IRAK-Un_t.AA CZAK 582-596 46 0.141678 1.68 In-house 204-218 (279) Show / Hide 
Range on Protein: 582-596
Range on HMM: 204-218/279
Sequence Identity: 46% (7 aa)

DVYCFGKVLLELVTG
||| || .| ...|.
DVYSFGMILWCIITC
Kinase IRAK-Un_t.AA Dicty4-Unclassified 582-596 53 0.14362 1.1 In-house 190-204 (263) Show / Hide 
Range on Protein: 582-596
Range on HMM: 190-204/263
Sequence Identity: 53% (8 aa)

DVYCFGKVLLELVTG
||| .. .| ||.||
DVYSYAMMLYELATG
Kinase IRAK-Un_t.AA TK-Unique 655-673 26 0.28085 0.31 In-house 276-294 (294) Show / Hide 
Range on Protein: 655-673
Range on HMM: 276-294/294
Sequence Identity: 26% (5 aa)

CLHGRASKRPQIRHVLKAL
|..  ...|| .| ... |
CWQWEPEERPSFRQIKHRL