Gene IRAK-Un_e (S.moellendorffii)
IRAK-Un_e
Species: S.moellendorffii
Alias: IRAK-Un_e
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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IRAK-Un_e.AA | Protein | None | 285 | None | Fasta, JSON |
IRAK-Un_e.NA | RNA | None | 858 | None | Fasta, JSON |
IRAK-Un_e.kin_dom | Protein Kinase Domain | None | 185 | None | Fasta, JSON |
Protein domains of IRAK-Un_e.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | IRAK-Un_e.AA | TKL | 1-265 | 21 | 1.1e-57 | 197.97 | In-house | 12-364 (364) | Show / Hide |
Range on Protein: 1-265 Range on HMM: 12-364/364 Sequence Identity: 21% (81 aa) GILQD---------GTVVAIKRSKSSANFGVMD-------------------------EQFLNEITILSQVNHRNLVKLKGWCMDTRRNA---------- |... |..||.|. || . .. ... .|| ..|. .| |.|...| |.. . . GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG PPLLVYEYVTNGTLLEHLQCKRGVVPLGWEQRLQIVIETAEALAYLHSVAA-----PPIYHRDVKSSNILLDDSLS--------------AKVADFGISK . .|.||. .|.||..|. |.||.......| ...|||| ||| ||| ||.|||.|. . .|..|||.|. QLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSR LV----GTGDAATTHV----------STLRIQGTPGYCDPELMT----------------TFRLTDKSDVYSFGVVLLELVTGQKPLDFGRESSRVNLAF . . | .|| | .. |||... ||.. | . |.||||||.|| |..|... . FMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-------------PY YSLPLIRMEMIEELVD-PKMGVVSAVER---------------CSVA--RVAALADKCLAECGANRPKMREVVEEL | .| . |.. .. |.|.. .| |. . ... |. .| .. .|| . |....| YDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | IRAK-Un_e.AA | IRAK | 5-193 | 32 | 3.9e-48 | 166.22 | In-house | 21-223 (317) | Show / Hide |
Range on Protein: 5-193 Range on HMM: 21-223/317 Sequence Identity: 32% (67 aa) DGTV--VAIK--RSKSSANFGVMDEQFLN---EITILSQVNHRNLVKLKGWCMDTRRNAPPLLVYEYVTNGTLLEHLQCKRGVVP---LGWEQRLQIVIE ..| .|.| .. . ... ....|. |. ... | |.| | | | .. . |||.| .||.| |.| | .| | | ||. | . KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQC---HCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWG TAEALAYLHSVA-APPIYHRDVKSSNILLDDSLSAKVADFGISKLV-GTGDAATTHV---STLRIQGTPGYCDPELMT--TFRLTDKSDVYSFGVVLLEL || .. .||.. . || |.|.||.|||||. . .| .||| ... . . | ...|| | || .. . .|| |.||||||.||||. TACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEV VTGQKP .||... LTGCRA |
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Kinase | IRAK-Un_e.AA | TKL-Unique | 6-193 | 30 | 5.5e-36 | 124.43 | In-house | 20-233 (290) | Show / Hide |
Range on Protein: 6-193 Range on HMM: 20-233/290 Sequence Identity: 30% (67 aa) GTVVAIKRSK--SSANFGVMDEQFLNEITILSQVN-HRNLVKLKGWCMDTRRNAPP--LLVYEYVTNGTLLEHLQ-------CKRGVVPLGWEQRLQIVI |. ||||. . .. .. .|.| | ||..... . | |.|.. |.||| .|| .| ||. |.| ..|. . .| ..||....| GYPVAIKQFHPNEDSSNEMMQE-FENEVNWMKKLHYHPNIVHYMGYCMD-HQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAI ETAEALAYLHSVAAPPIYHRDVKSSNILLDDS-----LSAKVADFGISKLVGTGDAATTHVST----LRIQGTPGYCDPELMTT--FRLTDKSDVYSFGV | .. |||. .| |.||| ||||.|.| ...|..|||.||. . .. |. .. .|.. . ||... . . ||||||||. DIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGI VLLELVTGQK------P || |..|.. | VLWEIATRKITKTYKKP |
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Kinase | IRAK-Un_e.AA | Pkinase | 5-191 | 26 | 4.2e-35 | 125.2 | Pfam | 23-209 (293) | Show / Hide |
Range on Protein: 5-191 Range on HMM: 23-209/293 Sequence Identity: 26% (52 aa) DGTVVAIKRSKSSANFGVMDEQFLN--EITILSQVNHRNLVKLKGWCMDTRRNAPPLLVYEYVTNG----TLLEHLQ--CKRGVVPLGWEQRLQIVIETA .| .||.|. | . . .|.. .. || |. .|| | |.|..|..| . . .| ||. .| | .... .... . ... .. ... TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQIL EALAYLHSVAAPPIYHRDVKSSNILLDDSLSA----KVADFGISKLVGTGDAATTHVSTLRIQGTPGYCDPELMT-TFRLTDKSDVYSFGVVLLELVTGQ ..|.|.|| | |||.|..|||.|. |..|||..|.. . . . |||.|. ||. . |.|..|.|..| |...|. RGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR |
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Kinase | IRAK-Un_e.AA | LRRK | 29-195 | 35 | 2.3e-34 | 118.98 | In-house | 106-284 (351) | Show / Hide |
Range on Protein: 29-195 Range on HMM: 106-284/351 Sequence Identity: 35% (67 aa) NEITILSQVNHRNLVKLKGWCMDTRRNAPPLLVYEYVTNGTLLEHLQCKRGVV------PLGWEQRLQIVIETAEALAYLHSVAAPPIYHRDVKSSNILL .|..|.| || |.|.||| |.. |. .| ||...|.| ..|. |. ..| .|.|... |....|||| ||| ||| || |||| HEVWIMSHLNHPNIVSLKGFCIH-----PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHN-PPIIHRDLKSPNILL ---D---------DSLSAKVADFGISKLVGTGDAATTHVSTLRIQGTPGYCDPELMT---TFRLTDKSDVYSFGVVLLELVTGQ-KPLD . . ||.|||||| . ..... . . |.||.. || | . |.|.|.||||..| ||.|.| | | WSSPQNHSPNYPNAHVCAKIADFGISR-MF---QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD |
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Kinase | IRAK-Un_e.AA | TK | 4-193 | 17 | 3e-31 | 101.4 | In-house | 50-394 (486) | Show / Hide |
Range on Protein: 4-193 Range on HMM: 50-394/486 Sequence Identity: 17% (60 aa) QDGTVVAIKRSKSSANFGVMDEQ------------FLNEITILSQVN-----HRNLVKLKGWCMDTRRN---------APPLLVYEYVTNGT----LLEH . | ||.| |. .. .... ||.| .... . | |.|.| | |.. . . |...| ||. .| |... GGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDY LQ-CKRGVVP------------------------------------------------------------------------LGWEQRLQIVIETAEALA |. |... . | .|.| . |.... LRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGME YLHSV----AAPPIYHRDVKSSNILLDDSLS-----------AKVADFGIS--------KLVGTGDAATTHV----------------STLRIQGTPG-- |||| . . |||. |.|..... .|.|||| | . .. .| ... . | . | YLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKL ---YCDPELMT---------TFRLTDKSDVYSFGVVLLELVT-GQKP .. || .. . . | ||||.||||.. |..| ||.| PIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP |
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Kinase | IRAK-Un_e.AA | Dicty4-Unclassified | 23-193 | 32 | 4.3e-30 | 100.24 | In-house | 41-207 (263) | Show / Hide |
Range on Protein: 23-193 Range on HMM: 41-207/263 Sequence Identity: 32% (58 aa) MDEQFLNEITILSQVNHRNLVKLKGWCMDT-RRNAPPLLVYEYVTNGTLLEHLQ--CKRGVVPLGWEQ--RLQIVIETAEALAYLHSVAAPPIYHRDVKS | . |. |. || . | ||||..| |. . | | |.|.| |. . . . .. | ...||.. . |||.|| MIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRN---FIHRDIKS SNILLDDSLSAKVADFGISKLVGTGDAATTHVSTLRIQGTPGYCDPELMTTFRLTDKSDVYSFGVVLLELVTGQKP ||||.| .|.|||||| . || | ||| || . . ||||||....| ||.|| | SNILMDKHFNIKIADFGISRVIDFNFNMTT------IAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDEP |
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Kinase | IRAK-Un_e.AA | Pkinase_Tyr | 1-193 | 29 | 2.7e-29 | 99.86 | Pfam | 18-214 (270) | Show / Hide |
Range on Protein: 1-193 Range on HMM: 18-214/270 Sequence Identity: 29% (61 aa) GILQ-----DGTVVAIKRSKSSANFGVMDEQ-----FLNEITILSQV-NHRNLVKLKGWCMDTRRNAP--PLLVYEYVTNGTLLEHLQCK-RGVVPLGWE |.. ... ||.| | | |.|| |..|. |..| .| |.|.| | |. .. | ...| ||. .| ||..|. . . || . GTWKGDPDNTKIPVAVKMLKE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT--DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMK QRLQIVIETAEALAYLHSVAAPPIYHRDVKSSNILLDDSLSAKVADFGISKLV-GTGDA-ATTHVSTLRIQGTPGYCDPELMTTFRLTDKSDVYSFGVVL . ||. .. |....||.| . |||. |.|..... .|..||| .... .. ... . | | .. || . . . | ||||.||||.. DLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMA----PECINYGKFTTKSDVWSFGVLM LELVT-GQKP |..| |..| WEIFTYGEQP |
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Kinase | IRAK-Un_e.AA | RIPK | 6-193 | 26 | 3.7e-29 | 96.48 | In-house | 18-227 (290) | Show / Hide |
Range on Protein: 6-193 Range on HMM: 18-227/290 Sequence Identity: 26% (56 aa) GTVVAIKRSKSSANF----GVMDEQFLNEITILSQVNHRNLVKLKGWCMDTRRNAPPL---LVYEYVTNGTLLEHLQCKR--GVVPLGWEQRLQIVIETA |..||.| ... .. . | .. . ... |...| | . .. .| || || | . |. | |. | | .. |.. GDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEIS EALAYLHSVAAPPIYHRDVKSSNILLDDSLSAKVADFGISKLVGTGDAAT-------THVSTLRIQ-GTPGYCDPELMT---TFR---LTDKSDVYSFGV .. |||| ||| ||| | .|||.| . .|.|||| .. .. . .. . . || | .||. . | |.|||||.. CGMCYLHSMN-PPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAI VLLELVTGQKP |. |. |. .| VMWEVLTQKHP |
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Kinase | IRAK-Un_e.AA | Dicty5 | 9-193 | 33 | 4.2e-29 | 97.32 | In-house | 25-202 (260) | Show / Hide |
Range on Protein: 9-193 Range on HMM: 25-202/260 Sequence Identity: 33% (64 aa) VAIKRSKSSAN-FGVMDEQFLNEITILSQVN--HRNLVKLKGWCMDTRRNAPPLLVYEYVTNGTLLEHLQCKRG--VVPLGWEQRLQIVIETAEALAYLH |||| |. | .. . | |.||.| . | |... | .. | | ||. ||.| . | .| |. . |.| . | | .. .|| VAIKVY-SQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYG--AHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLH SVAAPPIYHRDVKSSNILLDDSLSAKVADFGISKLVGTGDAATTHVSTLRIQGTPGYCDPELMTTFRLTDKSDVYSFGVVLLELVTGQKP |. | |||.|| |.|. . .|. |||.| | |.|| ||. . .|| . ..| ||||||.|| |. | | SMN---IIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHV------GTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEP |
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Kinase | IRAK-Un_e.AA | Dicty4 | 27-193 | 31 | 1.3e-28 | 92.73 | In-house | 45-216 (277) | Show / Hide |
Range on Protein: 27-193 Range on HMM: 45-216/277 Sequence Identity: 31% (56 aa) FLNEITILSQVNHRNLVKLKGWCMDTRRNAP--PLLVYEYVTNGTLLEHLQC----KRGVVPLGWEQRLQ---IVIETAEALAYLHSVAAPPIYHRDVKS |..|..|... | |.....| | | .| .. | ||. |.|.. | . ..| |. ... . . .| ...||. | | ||| || FRKEVHIMCKIRHPNICLFMGACT-APRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKS SNILLDDSLSAKVADFGISKLVGTGDAATTHVSTLRIQGTPGYCDPELMTTFRLTDKSDVYSFGVVLLELVTGQKP .|.| |... .||.|||.|.. .. .. .| |||.. || | . . |.|||||| || |..|.| | HNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMT--ACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEP |
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Kinase | IRAK-Un_e.AA | MLK | 8-193 | 27 | 1.8e-25 | 85.4 | In-house | 29-235 (291) | Show / Hide |
Range on Protein: 8-193 Range on HMM: 29-235/291 Sequence Identity: 27% (59 aa) VVAIKRSKSSANFGVMD-----EQFLNEITILSQVNHRN----LVKLKGWCMDTRRNAPPLLVYEYVTNGTLLEHLQCKRG-------------VVPLGW .||.|| .... . | ..| |. .|. ..|.| ....| | .. . ..| ||. .| | . | .|. |... IVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP--CHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDH-- EQRLQIVIETAEALAYLHSVAAPPIYHRDVKSSNILLDD------SLSAKVADFGISKLVGTGDAATTHVSTLRIQGTPGYCDPELM---TTFRLTDKSD .. ... |....|||| | .|| ||| ||.|||.|. . .|..|||.|. . . . |.. |. .||. . || . . |.| DHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSN---AGTYAWMAPEVIQQFRCEKYSEKCD VYSFGVVLLELVTGQKP |.|.|||| |..|.. | VWSWGVVLWEMLTREVP |
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Kinase | IRAK-Un_e.AA | S_TKc | 1-268 | 22 | 4.1e-21 | 77.37 | SMART | 18-231 (231) | Show / Hide |
Range on Protein: 1-268 Range on HMM: 18-231/231 Sequence Identity: 22% (64 aa) GILQD-GTVVAIKRSKSSANFGVMDEQFLNEITILSQVNHRNLVKLKGWCMDTRRNAPPLLVYEYVTN--GTLLEHLQCKRGV---VPLGWEQRLQIVIE .. . | .||||. | |....|| ||.. .| |.|||.... | .| ||. . |.|..... ... .|. . .. . CRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQ TAEALAYLHSVAAPPIYHRDVKSSNILLDDSLSAKVADFGISKLVGTGDAATTHVSTLRIQGTPGYCDPELMTTFRLTD-KSDVYSFGVVLLELVTGQKP ...||.|.|| | |||.| .|||||. |..|||..... . ||| |. ||.. . |.|..|.|..| |...|. | ICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPP LDFGRESSRVNLAFYSLPLIRMEMIEELVDPKMGVVSAVERCSVARVAALADKCLAECGANRPKMREVVE-E-----LTSI . ..|.. .. . . .||| ..|| |. . | . FP-----------------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | IRAK-Un_e.AA | TyrKc | 1-265 | 25 | 1.1e-17 | 63.39 | SMART | 18-280 (280) | Show / Hide |
Range on Protein: 1-265 Range on HMM: 18-280/280 Sequence Identity: 25% (73 aa) GILQDGTVVAIKRSKSSANFGVMDEQFLNEITILSQV--NHRNLVKLKGWCMDTRRN----APPLLVYEYVTNGTLLEHLQCKRGVVPLGWEQRLQIVIE |.. . ||.| |..| | |..|. |.... .| |.|.| | |.. || |...| ||. .| |...|. .|. | ... |.. . GTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--LCMKDLLSFCWQ TAEALAYLHSVAAPPIYHRDVKSSNILLDDSLSAKVADFGISKLVGTGDAATTHVSTLRIQ---GTPG-----YCDPELMTTFRLTDKSDVYSFGVVLLE |. .|||| .. ||| |.|... . .|..||| |. .. .|.. .. | . |. . . || . . . | ||||.||||.. | IACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWE LVTGQKPLDFG-----RESSRVNLAFYSLPLIRMEMIEELVDPKMGVVSAVERCSVARVAALADKCLAECGANRPKMREVVEEL . | .. | . ..| | ||. .. | | . | . . . .| .| ..|| ..|..|.. IFTYGQQPYPGMIQQMMSNQEV--IEYVKQGYRMPQPPNDY-P-MS--F---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | IRAK-Un_e.AA | IRAK | 213-265 | 20 | 1e-06 | 19.51 | In-house | 268-317 (317) | Show / Hide |
Range on Protein: 213-265 Range on HMM: 268-317/317 Sequence Identity: 20% (11 aa) IRMEMIEELVDPKMGVVSAVERCSVARVAALADKCLAECGANRPKMREVVEEL .|| .| ..|..|. ... ... . .| |.... ..|..|..|...| RRMQIYEKFIDHRMP---PCPPNMEKEMCQCACCCGHHRANRRCDMAWVMQQL |
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Kinase | IRAK-Un_e.AA | MLK | 246-265 | 30 | 0.000299 | 10.8 | In-house | 272-291 (291) | Show / Hide |
Range on Protein: 246-265 Range on HMM: 272-291/291 Sequence Identity: 30% (6 aa) KCLAECGANRPKMREVVEEL .| .. ..||..|..|..| QCWNQDPHKRPSFRQIVQHL |
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Kinase | IRAK-Un_e.AA | TK | 233-265 | 21 | 0.015808 | 3.43 | In-house | 454-486 (486) | Show / Hide |
Range on Protein: 233-265 Range on HMM: 454-486/486 Sequence Identity: 21% (7 aa) ERCSVARVAALADKCLAECGANRPKMREVVEEL ..| . .. | .| .. . || .....|.| PHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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Kinase | IRAK-Un_e.AA | Pkinase_Tyr | 253-265 | 38 | 3.05713 | 1.44 | Pfam | 258-270 (270) | Show / Hide |
Range on Protein: 253-265 Range on HMM: 258-270/270 Sequence Identity: 38% (5 aa) ANRPKMREVVEEL ..|| ..|..|.| EDRPTFSEIHEQL |