IRAK-Un_e

Species: S.moellendorffii
Alias: IRAK-Un_e
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_e.AA Protein None 285 None Fasta, JSON
IRAK-Un_e.NA RNA None 858 None Fasta, JSON
IRAK-Un_e.kin_dom Protein Kinase Domain None 185 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_e.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_e.AA TKL 1-265 21 1.1e-57 197.97 In-house 12-364 (364) Show / Hide
Range on Protein: 1-265
Range on HMM: 12-364/364
Sequence Identity: 21% (81 aa)

GILQD---------GTVVAIKRSKSSANFGVMD-------------------------EQFLNEITILSQVNHRNLVKLKGWCMDTRRNA----------
|...          |..||.|. ||  .   ..                         ... .|| ..|. .| |.|...| |.. . .           
GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG

PPLLVYEYVTNGTLLEHLQCKRGVVPLGWEQRLQIVIETAEALAYLHSVAA-----PPIYHRDVKSSNILLDDSLS--------------AKVADFGISK
 . .|.||. .|.||..|.         |.||.......| ...||||        ||| ||| ||.|||.|. .               .|..|||.|.
QLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSR

LV----GTGDAATTHV----------STLRIQGTPGYCDPELMT----------------TFRLTDKSDVYSFGVVLLELVTGQKPLDFGRESSRVNLAF
 .    .  | .||             | .. |||... ||..                  |  . |.||||||.|| |..|...              .
FMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-------------PY

YSLPLIRMEMIEELVD-PKMGVVSAVER---------------CSVA--RVAALADKCLAECGANRPKMREVVEEL
| .| . |..    ..   |.|..  .|               |. .  ... |. .| ..   .|| . |....|
YDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase IRAK-Un_e.AA IRAK 5-193 32 3.9e-48 166.22 In-house 21-223 (317) Show / Hide
Range on Protein: 5-193
Range on HMM: 21-223/317
Sequence Identity: 32% (67 aa)

DGTV--VAIK--RSKSSANFGVMDEQFLN---EITILSQVNHRNLVKLKGWCMDTRRNAPPLLVYEYVTNGTLLEHLQCKRGVVP---LGWEQRLQIVIE
..|   .|.|  ..  . ... ....|.    |. ...   | |.| | | | ..     . |||.| .||.|   |.|  | .|   | | ||. | . 
KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQC---HCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWG

TAEALAYLHSVA-APPIYHRDVKSSNILLDDSLSAKVADFGISKLV-GTGDAATTHV---STLRIQGTPGYCDPELMT--TFRLTDKSDVYSFGVVLLEL
|| .. .||..  . || |.|.||.|||||. . .| .|||       ...   . .    | ...||  |  || ..  . .|| |.||||||.||||.
TACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEV

VTGQKP
.||...
LTGCRA

Kinase IRAK-Un_e.AA TKL-Unique 6-193 30 5.5e-36 124.43 In-house 20-233 (290) Show / Hide
Range on Protein: 6-193
Range on HMM: 20-233/290
Sequence Identity: 30% (67 aa)

GTVVAIKRSK--SSANFGVMDEQFLNEITILSQVN-HRNLVKLKGWCMDTRRNAPP--LLVYEYVTNGTLLEHLQ-------CKRGVVPLGWEQRLQIVI
|. ||||. .  .. .. .|.| | ||.....  . | |.|.. |.|||    .||   .| ||.  |.| ..|.         .   .| ..||....|
GYPVAIKQFHPNEDSSNEMMQE-FENEVNWMKKLHYHPNIVHYMGYCMD-HQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAI

ETAEALAYLHSVAAPPIYHRDVKSSNILLDDS-----LSAKVADFGISKLVGTGDAATTHVST----LRIQGTPGYCDPELMTT--FRLTDKSDVYSFGV
  | .. |||.  .| |.||| ||||.|.|       ...|..|||.||.  . .. |.  ..       .|.. .  ||...   .  . ||||||||.
DIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGI

VLLELVTGQK------P
|| |..|..       |
VLWEIATRKITKTYKKP

Kinase IRAK-Un_e.AA Pkinase 5-191 26 4.2e-35 125.2 Pfam 23-209 (293) Show / Hide
Range on Protein: 5-191
Range on HMM: 23-209/293
Sequence Identity: 26% (52 aa)

DGTVVAIKRSKSSANFGVMDEQFLN--EITILSQVNHRNLVKLKGWCMDTRRNAPPLLVYEYVTNG----TLLEHLQ--CKRGVVPLGWEQRLQIVIETA
.| .||.|. | . .   .|.. ..  || |.  .|| | |.|..|..|   .  . .| ||. .|     | ....   ....  . ...   .. ...
TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQIL

EALAYLHSVAAPPIYHRDVKSSNILLDDSLSA----KVADFGISKLVGTGDAATTHVSTLRIQGTPGYCDPELMT-TFRLTDKSDVYSFGVVLLELVTGQ
..|.|.||     | |||.|..|||.|.        |..|||..|..         . .  . |||.|. ||.       . |.|..|.|..| |...|.
RGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR





Kinase IRAK-Un_e.AA LRRK 29-195 35 2.3e-34 118.98 In-house 106-284 (351) Show / Hide
Range on Protein: 29-195
Range on HMM: 106-284/351
Sequence Identity: 35% (67 aa)

NEITILSQVNHRNLVKLKGWCMDTRRNAPPLLVYEYVTNGTLLEHLQCKRGVV------PLGWEQRLQIVIETAEALAYLHSVAAPPIYHRDVKSSNILL
.|..|.|  || |.|.||| |..     |. .| ||...|.| ..|. |.          ..|  .|.|... |....||||   ||| ||| || ||||
HEVWIMSHLNHPNIVSLKGFCIH-----PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHN-PPIIHRDLKSPNILL

---D---------DSLSAKVADFGISKLVGTGDAATTHVSTLRIQGTPGYCDPELMT---TFRLTDKSDVYSFGVVLLELVTGQ-KPLD
   .         .   ||.||||||  .    .....  . .  |.||.. || |    .   |.|.|.||||..| ||.|.|  | |
WSSPQNHSPNYPNAHVCAKIADFGISR-MF---QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD

Kinase IRAK-Un_e.AA TK 4-193 17 3e-31 101.4 In-house 50-394 (486) Show / Hide
Range on Protein: 4-193
Range on HMM: 50-394/486
Sequence Identity: 17% (60 aa)

QDGTVVAIKRSKSSANFGVMDEQ------------FLNEITILSQVN-----HRNLVKLKGWCMDTRRN---------APPLLVYEYVTNGT----LLEH
.  | ||.|  |. ..   ....            ||.|  .... .     | |.|.| | |.. . .          |...| ||. .|     |...
GGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDY

LQ-CKRGVVP------------------------------------------------------------------------LGWEQRLQIVIETAEALA
|. |...  .                                                                        |  .|.| .    |....
LRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGME

YLHSV----AAPPIYHRDVKSSNILLDDSLS-----------AKVADFGIS--------KLVGTGDAATTHV----------------STLRIQGTPG--
||||       . . |||.   |.|.....            .|.|||| |        . .. .|  ...                 .    | . |  
YLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKL

---YCDPELMT---------TFRLTDKSDVYSFGVVLLELVT-GQKP
   .. || ..         . . | ||||.||||.. |..| ||.|
PIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP

Kinase IRAK-Un_e.AA Dicty4-Unclassified 23-193 32 4.3e-30 100.24 In-house 41-207 (263) Show / Hide
Range on Protein: 23-193
Range on HMM: 41-207/263
Sequence Identity: 32% (58 aa)

MDEQFLNEITILSQVNHRNLVKLKGWCMDT-RRNAPPLLVYEYVTNGTLLEHLQ--CKRGVVPLGWEQ--RLQIVIETAEALAYLHSVAAPPIYHRDVKS
| . |. |. ||  . | ||||..| |.      .    | |    |.|.|           |.  .    . . .. |  ...||..    . |||.||
MIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRN---FIHRDIKS

SNILLDDSLSAKVADFGISKLVGTGDAATTHVSTLRIQGTPGYCDPELMTTFRLTDKSDVYSFGVVLLELVTGQKP
||||.|    .|.||||||  .      ||      | |||    || .     . ||||||....| ||.||  |
SNILMDKHFNIKIADFGISRVIDFNFNMTT------IAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDEP

Kinase IRAK-Un_e.AA Pkinase_Tyr 1-193 29 2.7e-29 99.86 Pfam 18-214 (270) Show / Hide
Range on Protein: 1-193
Range on HMM: 18-214/270
Sequence Identity: 29% (61 aa)

GILQ-----DGTVVAIKRSKSSANFGVMDEQ-----FLNEITILSQV-NHRNLVKLKGWCMDTRRNAP--PLLVYEYVTNGTLLEHLQCK-RGVVPLGWE
|..      ... ||.|  |     | |.||     |..|. |..|  .| |.|.| | |.  ..  |  ...| ||. .| ||..|. .  .  ||  .
GTWKGDPDNTKIPVAVKMLKE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT--DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMK

QRLQIVIETAEALAYLHSVAAPPIYHRDVKSSNILLDDSLSAKVADFGISKLV-GTGDA-ATTHVSTLRIQGTPGYCDPELMTTFRLTDKSDVYSFGVVL
. ||. .. |....||.|     . |||.   |.|..... .|..||| ....  ..    ... . | |  ..    || . . . | ||||.||||..
DLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMA----PECINYGKFTTKSDVWSFGVLM

LELVT-GQKP
 |..| |..|
WEIFTYGEQP

Kinase IRAK-Un_e.AA RIPK 6-193 26 3.7e-29 96.48 In-house 18-227 (290) Show / Hide
Range on Protein: 6-193
Range on HMM: 18-227/290
Sequence Identity: 26% (56 aa)

GTVVAIKRSKSSANF----GVMDEQFLNEITILSQVNHRNLVKLKGWCMDTRRNAPPL---LVYEYVTNGTLLEHLQCKR--GVVPLGWEQRLQIVIETA
|..||.| ...            .. . |  .. .  ... |...| | .     ..    .| ||  || | . |. |      |. |  |  .. |..
GDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEIS

EALAYLHSVAAPPIYHRDVKSSNILLDDSLSAKVADFGISKLVGTGDAAT-------THVSTLRIQ-GTPGYCDPELMT---TFR---LTDKSDVYSFGV
..  ||||   ||| ||| | .|||.|  . .|.|||| ..  ..    .          .. . . ||  | .||.       .    | |.|||||..
CGMCYLHSMN-PPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAI

VLLELVTGQKP
|. |. |. .|
VMWEVLTQKHP

Kinase IRAK-Un_e.AA Dicty5 9-193 33 4.2e-29 97.32 In-house 25-202 (260) Show / Hide
Range on Protein: 9-193
Range on HMM: 25-202/260
Sequence Identity: 33% (64 aa)

VAIKRSKSSAN-FGVMDEQFLNEITILSQVN--HRNLVKLKGWCMDTRRNAPPLLVYEYVTNGTLLEHLQCKRG--VVPLGWEQRLQIVIETAEALAYLH
||||   |. | ..   . |  |.||.| .   | |...  |    ..    |  | ||. ||.| . |  .|     |. . |.| . |  | .. .||
VAIKVY-SQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYG--AHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLH

SVAAPPIYHRDVKSSNILLDDSLSAKVADFGISKLVGTGDAATTHVSTLRIQGTPGYCDPELMTTFRLTDKSDVYSFGVVLLELVTGQKP
|.    | |||.|| |.|.   . .|. |||.|  |      |.||      ||. .  .|| .    ..| ||||||.|| |. |   |
SMN---IIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHV------GTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEP

Kinase IRAK-Un_e.AA Dicty4 27-193 31 1.3e-28 92.73 In-house 45-216 (277) Show / Hide
Range on Protein: 27-193
Range on HMM: 45-216/277
Sequence Identity: 31% (56 aa)

FLNEITILSQVNHRNLVKLKGWCMDTRRNAP--PLLVYEYVTNGTLLEHLQC----KRGVVPLGWEQRLQ---IVIETAEALAYLHSVAAPPIYHRDVKS
|..|..|...  | |.....| |    | .|  .. | ||.  |.|.. |      .   ..| |. ...   . . .|  ...||.   | | ||| ||
FRKEVHIMCKIRHPNICLFMGACT-APRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKS

SNILLDDSLSAKVADFGISKLVGTGDAATTHVSTLRIQGTPGYCDPELMTTFRLTDKSDVYSFGVVLLELVTGQKP
.|.| |... .||.|||.|..  ..   ..  .|    |||..  || |   . . |.|||||| || |..|.| |
HNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMT--ACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEP

Kinase IRAK-Un_e.AA MLK 8-193 27 1.8e-25 85.4 In-house 29-235 (291) Show / Hide
Range on Protein: 8-193
Range on HMM: 29-235/291
Sequence Identity: 27% (59 aa)

VVAIKRSKSSANFGVMD-----EQFLNEITILSQVNHRN----LVKLKGWCMDTRRNAPPLLVYEYVTNGTLLEHLQCKRG-------------VVPLGW
.||.|| ....   . |     ..|  |. .|. ..|.|     ....| | ..    . ..| ||. .| | . |  .|.             |...  
IVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP--CHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDH--

EQRLQIVIETAEALAYLHSVAAPPIYHRDVKSSNILLDD------SLSAKVADFGISKLVGTGDAATTHVSTLRIQGTPGYCDPELM---TTFRLTDKSD
.. ...    |....|||| | .|| ||| ||.|||.|.       . .|..|||.|. . . .  |.. |.   .||. .  ||        . . |.|
DHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSN---AGTYAWMAPEVIQQFRCEKYSEKCD

VYSFGVVLLELVTGQKP
|.|.|||| |..|.. |
VWSWGVVLWEMLTREVP

Kinase IRAK-Un_e.AA S_TKc 1-268 22 4.1e-21 77.37 SMART 18-231 (231) Show / Hide
Range on Protein: 1-268
Range on HMM: 18-231/231
Sequence Identity: 22% (64 aa)

GILQD-GTVVAIKRSKSSANFGVMDEQFLNEITILSQVNHRNLVKLKGWCMDTRRNAPPLLVYEYVTN--GTLLEHLQCKRGV---VPLGWEQRLQIVIE
..  . | .||||. |         |....|| ||.. .| |.|||.... |        .| ||. .  |.|..... ...    .|.   .   .. .
CRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQ

TAEALAYLHSVAAPPIYHRDVKSSNILLDDSLSAKVADFGISKLVGTGDAATTHVSTLRIQGTPGYCDPELMTTFRLTD-KSDVYSFGVVLLELVTGQKP
...||.|.||     | |||.| .|||||.    |..|||.....              . ||| |. ||..     .  |.|..|.|..| |...|. |
ICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPP

LDFGRESSRVNLAFYSLPLIRMEMIEELVDPKMGVVSAVERCSVARVAALADKCLAECGANRPKMREVVE-E-----LTSI
 .                   ..|.. ..                 .  . .|||    ..||   |. . |        .
FP-----------------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase IRAK-Un_e.AA TyrKc 1-265 25 1.1e-17 63.39 SMART 18-280 (280) Show / Hide
Range on Protein: 1-265
Range on HMM: 18-280/280
Sequence Identity: 25% (73 aa)

GILQDGTVVAIKRSKSSANFGVMDEQFLNEITILSQV--NHRNLVKLKGWCMDTRRN----APPLLVYEYVTNGTLLEHLQCKRGVVPLGWEQRLQIVIE
|..   . ||.|  |..|      | |..|. |....  .| |.|.| | |..  ||     |...| ||. .| |...|. .|.   | ... |.. . 
GTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--LCMKDLLSFCWQ

TAEALAYLHSVAAPPIYHRDVKSSNILLDDSLSAKVADFGISKLVGTGDAATTHVSTLRIQ---GTPG-----YCDPELMTTFRLTDKSDVYSFGVVLLE
 |.  .||||    .. |||    |.|... . .|..||| |. .. .|..    .. | .   |. .      . || . . . | ||||.||||.. |
IACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWE

LVTGQKPLDFG-----RESSRVNLAFYSLPLIRMEMIEELVDPKMGVVSAVERCSVARVAALADKCLAECGANRPKMREVVEEL
. |  ..   |      . ..|    |     ||.  ..   | |   .    |  . .  .  .| .|  ..|| ..|..|..
IFTYGQQPYPGMIQQMMSNQEV--IEYVKQGYRMPQPPNDY-P-MS--F---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase IRAK-Un_e.AA IRAK 213-265 20 1e-06 19.51 In-house 268-317 (317) Show / Hide
Range on Protein: 213-265
Range on HMM: 268-317/317
Sequence Identity: 20% (11 aa)

IRMEMIEELVDPKMGVVSAVERCSVARVAALADKCLAECGANRPKMREVVEEL
.||  .| ..|..|.    ... ...  . .|  |.... ..|..|..|...|
RRMQIYEKFIDHRMP---PCPPNMEKEMCQCACCCGHHRANRRCDMAWVMQQL

Kinase IRAK-Un_e.AA MLK 246-265 30 0.000299 10.8 In-house 272-291 (291) Show / Hide
Range on Protein: 246-265
Range on HMM: 272-291/291
Sequence Identity: 30% (6 aa)

KCLAECGANRPKMREVVEEL
.|  .. ..||..|..|..|
QCWNQDPHKRPSFRQIVQHL

Kinase IRAK-Un_e.AA TK 233-265 21 0.015808 3.43 In-house 454-486 (486) Show / Hide
Range on Protein: 233-265
Range on HMM: 454-486/486
Sequence Identity: 21% (7 aa)

ERCSVARVAALADKCLAECGANRPKMREVVEEL
..|  . .. |  .| ..  . || .....|.|
PHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase IRAK-Un_e.AA Pkinase_Tyr 253-265 38 3.05713 1.44 Pfam 258-270 (270) Show / Hide
Range on Protein: 253-265
Range on HMM: 258-270/270
Sequence Identity: 38% (5 aa)

ANRPKMREVVEEL
..|| ..|..|.|
EDRPTFSEIHEQL