Gene IRAK-Un_dj (S.moellendorffii)

IRAK-Un_dj

Species: S.moellendorffii
Alias: IRAK-Un_dj
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_dj.AA Protein None 381 None Fasta, JSON
IRAK-Un_dj.NA RNA None 1146 None Fasta, JSON
IRAK-Un_dj.kin_dom Protein Kinase Domain None 156 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_dj.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_dj.AA TKL 174-262 20 1e-15 53.1 In-house 120-199 (364) Show / Hide 
Range on Protein: 174-262
Range on HMM: 120-199/364
Sequence Identity: 20% (22 aa)

MPNGDLASALRRGDEFKSSDGETSESSDSSSAGSAKPLDWITRFKIAIGVAEALAFLHHDCS-----PAVIHRDLKSSSVFLDEGYE-------------
.|.|.| . |                             |  |...|...| ....|| .       |..|||||||. ...|| ..             
CPGGSLLHYLH----------------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-VRLGSFG
 . .. ||
CCKICDFG
Kinase IRAK-Un_dj.AA IRAK 209-252 40 3.8e-12 39.48 In-house 104-148 (317) Show / Hide 
Range on Protein: 209-252
Range on HMM: 104-148/317
Sequence Identity: 40% (18 aa)

KPLDWITRFKIAIGVAEALAFLHHDCSP-AVIHRDLKSSSVFLDE
||| |..|..|..| | .. ||| . .  ..||.| ||. . ||.
KPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQ
Kinase IRAK-Un_dj.AA LRRK 174-250 29 5.2e-12 38.78 In-house 137-199 (351) Show / Hide 
Range on Protein: 174-250
Range on HMM: 137-199/351
Sequence Identity: 29% (24 aa)

MPNGDLASALR--RGDEF---KSSDGETSESSDSSSAGSAKPLDWITRFKIAIGVAEALAFLHHDCSPAVIHRDLKSSSVFL
.|.||| . |.  . |.|   |                    ..| .. |||. .|.....| |...| .|||||||  ..|
APHGDLYHFLHNKKQDGFHFMK------------------AHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNILL
Kinase IRAK-Un_dj.AA LISK 177-245 33 1.5e-09 26.95 In-house 82-129 (296) Show / Hide 
Range on Protein: 177-245
Range on HMM: 82-129/296
Sequence Identity: 33% (23 aa)

GDLASALRRGDEFKSSDGETSESSDSSSAGSAKPLDWITRFKIAIGVAEALAFLHHDCSPAVIHRDLKS
|||   |.. |.                    .|| |  | ||| ..|.....||   |  .|||||||
GDLHQYLKDMDK------------------HKIPLPWPQRVKIALDIACGMSYLH---SMNIIHRDLKS
Kinase IRAK-Un_dj.AA Dicty5 209-262 31 3.2e-09 27.87 In-house 95-149 (260) Show / Hide 
Range on Protein: 209-262
Range on HMM: 95-149/260
Sequence Identity: 31% (18 aa)

K----PLDWITRFKIAIGVAEALAFLHHDCSPAVIHRDLKSSSVFLDEGYEVRLGSFG
|    |. . ..  .||..| .. .||   |  .|||||||  . . | ... .  ||
KTTGQPIAYFQQLHMAIDIAQSMRHLH---SMNIIHRDLKSMNFLITENWKIKIIDFG
Kinase IRAK-Un_dj.AA TKL-Unique 209-262 35 5.3e-09 28.06 In-house 105-162 (290) Show / Hide 
Range on Protein: 209-262
Range on HMM: 105-162/290
Sequence Identity: 35% (21 aa)

KPLDWITRFKIAIGVAEALAFLHHDCSPAVIHRDLKSSSVFLDEG-----YEVRLGSFG
..|..  | |.|| .| .. .|||   | .||||||||.. .|..     . ...  ||
CKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFG
Kinase IRAK-Un_dj.AA MLK 217-256 28 2.2e-08 25.34 In-house 127-171 (291) Show / Hide 
Range on Protein: 217-256
Range on HMM: 127-171/291
Sequence Identity: 28% (13 aa)

FKIAIGVAEALAFLHHDCSPAVIHRDLKSSSVFLDE-----GYEV
...|  .|.....|| .  ...|||||||. . .||     ....
MNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGT
Kinase IRAK-Un_dj.AA GCN2 217-262 39 2.5e-08 24.83 In-house 311-353 (511) Show / Hide 
Range on Protein: 217-262
Range on HMM: 311-353/511
Sequence Identity: 39% (18 aa)

FKIAIGVAEALAFLHHDCSPAVIHRDLKSSSVFLDEGYEVRLGSFG
....... |.|...|   | ..|||||| | .|||.   |. | ||
WRYFRQILEGLNYIH---SQGMIHRDLKPSNIFLDCCGNVKIGDFG
Kinase IRAK-Un_dj.AA LISK-DD1 209-245 51 4.8e-08 25.43 In-house 118-151 (290) Show / Hide 
Range on Protein: 209-245
Range on HMM: 118-151/290
Sequence Identity: 51% (19 aa)

KPLDWITRFKIAIGVAEALAFLHHDCSPAVIHRDLKS
.|. |  | ||| ..|.| |.||   |  .|||||||
IPIPWKLRVKIALDIACAMAYLH---SKNIIHRDLKS
Kinase IRAK-Un_dj.AA DRK 211-262 36 9.9e-08 22.3 In-house 95-145 (258) Show / Hide 
Range on Protein: 211-262
Range on HMM: 95-145/258
Sequence Identity: 36% (19 aa)

LDWITRFKIAIGVAEALAFLHHDCSPAVIHRDLKSSSVFLDEGYEVRLGSFG
.||  . .... .|  . .||  | | .|||||||     || . |    ||
MDWPLMKQMMFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQVKVADFG
Pkinase IRAK-Un_dj.AA Pkinase 107-259 11 1.2e-07 28.13 Pfam 31-154 (293) Show / Hide 
Range on Protein: 107-259
Range on HMM: 31-154/293
Sequence Identity: 11% (19 aa)

VVIKSVESREMFDA-----EVAMLAGLGHSSSANRFVQIIGICSSSSAGGGGGGGGDCADGHAQRMLLVLRQMPNG----DLASALRRGDEFKSSDGETS
.. |. |. ..  .     |..... |.|       |...... .                  ... .|.  ...|    ||.. ...            
IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN----IVRLYDWFED-----------------KDHIYMVMEYCEGGLYVMDLFDYIST------------

ESSDSSSAGSAKPL--DWITRFKIAIGVAEALAFLHHDCSPAVIHRDLKSSSVFLDEGYEV----RLG
         . ...  .. .  ...  ....|...|      .||||||.. ...|. ...    ...
--------WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKIC
TyrKc IRAK-Un_dj.AA TyrKc 84-368 14 6e-06 -126.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 84-368
Range on HMM: 1-280/280
Sequence Identity: 14% (50 aa)

FAQGNLLREG----LFAGTLGGDGKEAVVIKSVE--SREMFDAEVAMLAGL--GHSSSANRFVQIIGICSSSSAGGGGGGGGDCADGHA---QRMLLVLR
   |  | ||     . ||.     . | .|..   .||.|  |  ..  |   |       |...|.|....                   . ...|. 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDAREDFMREARIMCKLGGHH----PNIVRLYGVCTQQGRN-------------FMYIEPLMIVME

QMPNGDLASALRRGDEFKSSDGETSESSDSSSAGSAKPLDWITRFKIAIGVAEALAFLHHDCSPAVIHRDLKSSSVFLDEGYEVRLGSFGKACRQQYGSD
 ||.||| . ||.  .                      | . .  .... .|.  ..||.     .|||||    . ..|.. |. . || .        
YMPHGDLKDYLRKHRPK---------------------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSR-------

VFPVYDIYCY---GKVLLDLVSGLDISS----CCDGFG-------EAWLHR----------------------ALPLME-----FGKRDAFLRLVDPTLV
     ||| .   |      .|.  ...    ....         |.. ..                      . |  .        .... .. .    
-----DIYDDDQQG------ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM

LDEDHV-------KELMLLAVIAKSCLDPEHAQHQTMSNVLHML
   ...           .   | |.| . . ..  |.|.. . .
PQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
S_TKc IRAK-Un_dj.AA S_TKc 84-351 12 0.000104 -107.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 84-351
Range on HMM: 1-231/231
Sequence Identity: 12% (39 aa)

FAQGNLLREGLFAGTLGGDGKE---AVVIKSVESREMFDAEVAMLAGLGHSSSANRFVQIIGICSSSSAGGGGGGGGDCADGHAQRMLLVLRQMPN--GD
.  .... .| |.    .  |.    | || .   |..  |...|            |...... .                  ... .|.  ...  ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-----HHPNIVKLYDVFQD------------------DHLYMVMEYCDGDLGD

LASALRRGDE----FKSSDGETSESSDSSSAGSAKPLDWITRFKIAIGVAEALAFLHHDCSPAVIHRDLKSSSVFLDEGYEVRLGSFGKACRQQYGSDVF
| . ...       |. .  ..                     ...  ...||...|      .|||||| . ..|||  .. .. || |..        
LFDYIKKRGRHGLRFPFPE-HAR--------------------FYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL-------

PVYDIYC------------YGK----------VLLDLVSGLDISSCCDGFGEAWLHRALPLMEFGKRDAFLRLVDPTLVLDED---HVKELML--LAVIA
   . .|            |||          .|  ...|    .      .. ... .        . .. ...  |. | .    . |..   ... .
---TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

KSCL
   .
HPWF